The following is an edited excerpt.
Schizophrenia is thought to have a substantial genetic background which is also, to some extent, population-specific. Genome-wide searches have revealed many numerous genomic variants with weak effects, but the remaining ‘missing heritability’ is unknown. Scientists hypothesize that it may be partly explained by rare variants with large effect.
Since the 1960s, biologists have been hunting for substances made by the body that might accumulate in abnormally high levels to produce the symptoms associated with schizophrenia. In particular, there was a search for chemicals that might be related to the hallucinogens phencyclidine (PCP) or lysergic acid diethylamide (LSD), which could explain the emergence of psychotic symptoms in schizophrenia.
Read the full article here: GRIN3A And The Hunt For A Genetic Cause Of Schizophrenia