Genomic sequencing identifies carcinogen in herbal remedy

Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments such as arthritis, gout and inflammation.

The discovery is described in the Aug. 7 issue of Science Translational Medicine.

This study illustrates how genomic sequencing could also be used to pinpoint a culprit carcinogen in some cancer clusters, says Margaret L. Hoang, Ph.D., lead author of the study.

Read the full, original story here: Scientists Use Genome Sequencing to Demonstrate Herbal Remedy Causes Upper Urinary Tract Cancers

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