Precision gene editing paves way for monkey models of genetic disease

| November 7, 2013
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Image via Nature. Credit: Rod Williams/
This article or excerpt is included in the GLP’s daily curated selection of ideologically diverse news, opinion and analysis of biotechnology innovation.

Anthony Chan spent two years creating the first five monkeys in the world to be genetically engineered with human mutations — in this case, for Huntington’s disease. But three of the five monkeys, reported in 2008, developed severe symptoms of Huntington’s much more quickly than anticipated, and had to be killed within a month of birth.

Chan, a geneticist at Emory University in Atlanta, Georgia, and other scientists around the world are now eyeing precision genome-editing techniques that solve such problems by using enzymes and RNA instead of viruses. Many have high hopes that transgenic monkeys will mimic human genetic conditions more faithfully than mice — and thus permit better drug-development tests and accelerate basic research in neuro­science.

Read the full, original story here: Precision gene editing paves way for transgenic monkeys

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