Mutations in gene causes metabolic syndrome in Iranian families

Genetic mutations causing an inherited form of the metabolic syndrome have been found, with implications for drug development across diabetes, heart disease, and obesity.

A substitution error in the gene DYRK1B tracked exactly with early-onset coronary artery disease, abdominal obesity, hypertension, and type 2 diabetes running in three large families in Iran, Arya Mani, MD, of Yale, and colleagues found.

A second substitution mutation in the same gene was found in affected, but not unaffected, members in a fourth family of a different ethnic background, the group reported in the May 15 issue of the New England Journal of Medicine.

The specific mutations found are likely rare, but genome-wide association studies have also linked DYRK1B to type 2 diabetes and traits associated with the metabolic syndrome, which may implicate common variants in the general population, the group noted.

ADVERTISEMENT

Read the full, original story: Metabolic Syndrome: Genetic Trigger?

Outbreak Daily Digest
Biotech Facts & Fallacies
GLP Podcasts
Infographic: Here’s where GM crops are grown around the world today

Infographic: Here’s where GM crops are grown around the world today

Do you know where biotech crops are grown in the world? This updated ISAAA infographics show where biotech crops were ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

* indicates required
Email Lists
Send this to a friend