Researchers have traced genetic changes in a bacterial pathogen over 450 years, and claim that epidemics of bacterial disease in human history may be caused by chance environmental changes rather than genetic mutations.
In a study published in PNAS, a team led by the University of Warwick analysed 149 genomes ofSalmonella enterica serovar Paratyphi A, which is a major cause of enteric fever. Enteric fever is currently estimated at 27 million clinical cases each year, resulting in 200,000 deaths.
Lead author, Zhemin Zhou from Warwick Medical School, said: “When epidemics break out, many scientists suspect they have been driven by increased virulence or fitness, possibly associated with the gain of novel genes or mutations. We wanted to trace genetic changes in a prominent bacterial pathogen back to see if this was true.”
The team reconstructed the genealogy, global transmission history and evolutionary history and found the pathogen originated at least 450 years ago, and had not changed dramatically over the centuries. This suggests that the pathogen had not become more efficient at causing enteric fever.
Zhemin Zhou said: “We found the pathogen formed seven distinct lineages that spread globally since the mid-19th century. Tracing the pathogen, we found there were genetic mutations that may have transiently improved drug resistance or improved the metabolic efficiency. However, most mutations were short-lived and removed by evolutionary forces.”
Read the full, original story: Epidemic outbreaks caused by environment, not evolution