Chemo drug uses cells’ natural defense mechanism to slow cancer growth

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis. 

A type of chemotherapy drug appears to work by tricking cells into thinking they’re infected with viruses, according to Canadian researchers studying bowel cancer cells.

The new research, published in the journal Cell, overturns the previous view that these drugs switch off some of the genes responsible for cell growth.

The discovery suggests that the treatment, called a ‘hypomethylating’ drug, could have wider uses. It could also lead to new combinations of existing therapies, and even the development of completely new drugs, the researchers say.

One of the drugs, decitabine, works by stripping a cell’s DNA of tiny molecular tags, known as epigenetic tags.

This changes gene activity, causing cells to stop growing. But exactly which genes are affected has remained a mystery.

The researchers showed that, rather than directly affecting genes involved in cell growth, decitabine reawakened long-dormant viruses hidden in the human genome. This triggered the cell’s anti-virus systems to halt cell growth.

Read full, original post: Chemo drug works by tricking cells into thinking they’re infected



Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Video: Test everyone – Slovakia goes its own way to control COVID

Video: Test everyone – Slovakia goes its own way to control COVID

As Europe sees record coronavirus cases and deaths, Slovakia is testing its entire adult population. WSJ's Drew Hinshaw explains how ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend