Ribosomal DNA may hold key to heritable diseases

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis.

The study…by [the] University of Cambridge and King’s College London shows that the genetic variation of ribosomal DNA (rDNA) could be driving how the environment within the womb determines an offspring’s attributes.

Lead researcher Professor Vardhman Rakyan…said: “These studies only looked at a single copy part of individuals’ genomes and never at ribosomal DNA…This could be the reason why we’ve only so far been able to explain a small fraction of the heritability of many health conditions[.]”


A major contributor to this process is ‘epigenetics’…It has been proposed that in response to a poor in-utero environment, an offspring’s epigenetic profile will change.

Professor Rakyan said: “Initially, we found nothing…but then…[w]e looked at the ribosomal DNA data and found huge epigenetic differences.

[O]nly about 20[%] of the heritability of type 2 diabetes has been explained by genome studies…The major role that genetic variation of rDNA appears to have and the fact that rDNA analysis would not have been included in these studies could explain some of this missing heritability.


Read full, original post: Missing link in genetics could explain conundrum of disease inheritance

Outbreak Daily Digest
Biotech Facts & Fallacies
GLP Podcasts
Infographic: Deaths from COVID-19 are far higher than reported estimates

Infographic: Deaths from COVID-19 are far higher than reported estimates

More than 2.8 million people have lost their lives due to the pandemic, according to a Wall Street Journal analysis ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend