New opioid promises ‘gold standard’ pain relief without the addiction

opioid

Opioid drugs like morphine and Oxycontin are still held as the gold standard when it comes to relieving pain. But it has become brutally obvious that opioids have dangerous side effects, including physical dependence, addiction and the impaired breathing that too often leads to death from an overdose. Researchers have long been searching for a drug that would relieve pain without such a heavy toll.

Now a study in monkeys published in Science Translational Medicine shows a new type of opioid drug met all the criteria on drug developers’ wish list. The findings even suggest that instead of causing addiction, the new compound might be used to curb addiction and pain all at once.

Opioid drugs relieve pain by acting at four types of opioid receptors found throughout the nervous system. The mu opioid receptor is primarily responsible for opioids’ pain-relieving effects.

Related article:  ASMR: Being triggered by 'ordinary sounds and sights' may be more than pseudoscience

Studies of [another receptor,] NOP, have shown that it too has analgesic effects in rodents—but seemingly without the side effects.

Even at higher doses, AT-121 did not cause the side effects that make most opioids so dangerous—suppression of breathing and heart rate, itch and physical dependence (in which stopping use leads to withdrawal symptoms). Even after several doses AT-121 retained its analgesic effect whereas most opioids require an increasing dosage over time to achieve pain relief.

Read full, original post: Too Good to Be True? A Nonaddictive Opioid without Lethal Side Effects Shows Promise

Outbreak
Outbreak Daily Digest
Biotech Facts & Fallacies
Genetics Unzipped
Infographic: How dangerous COVID mutant strains develop

Infographic: How dangerous COVID mutant strains develop

Sometime in 2019, probably in China, SARS CoV-2 figured out a way to interact with a specific "spike" on the ...
Untitled

Philip Njemanze: Leading African anti-GMO activist claims Gates Foundation destroying Nigeria

Nigerian anti-GMO activist, physician, and inventor pushes anti-gay and anti-GMO ...

Most Popular

News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend