Can big data fight cancer by identifying those genetically predisposed to disease?


Present-day cancer care is reactive. When an individual begins to have symptoms of cancer, a tumor has typically already formed and may have begun to invade surrounding tissue. Metastatic cancer — the spread of cancer to somewhere other than the primary tumor site — may have developed, too. Once cancer has spread to other areas of the body, the prognosis is poor. But a new method for identifying cancer predisposition genes could help speed up the shift to proactive cancer care.

Levi MacIntosh (not his real name), a 38-year-old media creator in British Columbia, Canada, lost his uncle six years ago to terminal cancer that had spread to several organ systems. “He was only in his mid-fifties and hardly had any symptoms before he was diagnosed,” MacIntosh told Genetic Literacy Project. Since the cancer was so advanced and widespread, doctors had trouble determining where in the body it had originated. “It would have been great if [the doctors] had been able to tell what was happening a lot earlier. He was in the prime of his life.”

MacIntosh’s experience is an all-too familiar one for countless friends and loved ones of those diagnosed with late stage or terminal cancer. And for those who survive their own cancer diagnoses, the treatments themselves can leave behind a series of physical and emotional scars.

Long-term effects of surgical cancer treatments can include infertility, nerve damage, chronic pain, phantom limb syndrome following amputation, and lymphedema. Long-term effects of chemotherapy can include increased risk of developing leukemia, hearing loss, kidney failure, heart problems, lung disease, and immune system dysfunction. And long-term effects of radiation can include damage to the heart and lungs, development of additional cancers, troublesome or painful skin changes, and bladder and bowel control problems. It’s not uncommon for a cancer patient to receive all three forms of treatment.

Additionally, the experience of cancer diagnosis and treatment in general is associated with long-lasting psychosocial effects, as well as increased rates of depression, anxiety, post-traumatic stress disorder, and exacerbation of pre-existing mental health conditions.

Since one in three of all North Americans will be diagnosed with at least one form of cancer in their lifetimes, the impact of a reactive cancer care system is far-reaching. The ideal form of cancer care is proactive, where preventative steps are taken well before symptoms appear and where an individual’s cancer risk is known and tracked over their lifetime.

cancer 9 21 18 2

Proactive cancer care would reduce the number of lives lost, and would also minimize the financial and physical hardships associated with cancer treatments. The evolution from reactive to proactive care is only in its infancy, but research into the genes that predispose an individual to developing certain cancers helps form an important basis for future proactive cancer care measures.

Researchers at the Centre for Genomic Regulation in Barcelona have developed a new method for identifying genes that contribute to heritable cancer risk. The new research, published in Nature Communications in July, marks a major win for big data analysis, and signifies a move in the direction of improved cancer predisposition gene discovery. It’s been estimated that five to 10 percent of all cancers are linked to inheritance of cancer predisposition genes (CPGs), but some research puts the percentage much higher — at nearly 35 percent.

Related article:  Chasing the 'warrior gene' and why it looks like a dud so far

“Now we have a powerful tool to detect new cancer predisposition genes and, consequently, to contribute to improving cancer diagnosis and prevention in the future,” said Solip Park, first author of the study. If a person’s cancer predisposition genes are known, screening and testing can begin long before symptoms arise, and steps could be taken to help prevent malignant tumor formation.

The team was led by ICREA Research Professor, Ben Lehner, and though they identified just 10 CPGs (and three previously-identified ones), these genes account for one in 50 of all cancer cases. ALFRED, the new statistical method that was used to discover the genes, is less expensive and more efficient than earlier methods.

The researchers relied on publicly available genome data from global cancer studies like The Cancer Genome Atlas project. ALFRED was applied to the genome sequences of over 10,000 cancer patients spanning 30 different cancer types. Genetic information from the cancer patients’ tumor cells was compared to their own non-tumor (non-cancerous) cells.

ALFRED (“allelic loss featuring rare damage”) was specifically used to test Alfred Knudson’s two-hit hypothesis, which has been a framework for CPG discovery for over four decades. The two-hit hypothesis states that for a cell to become cancerous and lead to tumor formation, both copies of the cell’s tumor suppressor genes

Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

Genetic mutations that can contribute to the development of cancer in an individual are inherited or acquired. Acquired mutations can be caused by several factors, including DNA replication errors or UV exposure from the sun. Previous research using large-scale genome sequencing has played a big role in identifying cancers driven by the latter group, called somatic mutations, but the identification of inherited cancer risk genes has not been as productive.

For cancer to develop, according to the two-hit hypothesis, an individual needs to have a harmful inherited genetic variant (or CPG) plus the addition of an acquired somatic mutation. These “two hits” knock out the function of a tumor suppressor gene, thus blocking the cell’s abilities to keep unwanted and harmful (cancerous) cell growth in check.

The work of Lehner et al. shows that Knudson’s hypothesis can be utilized to identify CPGs from cancer exomes without the use of control groups. ALFRED, the unique statistical method used by the researchers, was able to identify CPGs that lead to cancer through a combination of inherited and somatic mutations.

What’s more, Lehner said, “our work highlights how important it is to share genomic data. … We combined data from many different projects and by applying a new computational method were able to identify important cancer genes that were not identified by the original studies. Many patient groups lobby for better sharing of genomic data because it is only by comparing data across hospitals, countries and diseases that we can obtain a deep understanding of many rare and common diseases.”

Kristen Hovet is a journalist and writer who specializes in psychology, health, science and the intersection of sociology and culture. Follow her on her website,  Facebook or Twitter @kristenhovet

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
can you boost your immune system to prevent coronavirus spread x

Video: How to boost your immune system to guard against COVID and other illnesses

Scientists have recently developed ways to measure your immune age. Fortunately, it turns out your immune age can go down ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend