Immunotherapy more effective in patients with more cancer mutations, study shows

immunotherapy

The number of mutations in a tumor’s genome may predict how well a patient will benefit from treatment with immune checkpoint inhibitors, drugs that take the brakes off the immune system, according to a largescale study published [January 14] in Nature Genetics.

In the current study, a team of scientists led by Luc Morris of Memorial Sloan Kettering Cancer Center in New York City analyzed clinical information and DNA sequence data from 1,662 patients with advanced cancer who had been treated with checkpoint inhibitors. They found that, in general, people with a higher [higher tumor mutational burden] responded better to the drugs than those with a lower mutational burden, although the relationship varied substantially across tumors. In glioma, for example, patients with a higher TMB didn’t show any advantage over those with a lower TMB.

Related article:  Keen sense of smell? You're probably good at not getting lost, study suggests

It’s not yet clear why more tumor mutations are linked with improved treatment outcomes. One popular theory is that a higher TMB makes a tumor cell appear more different from a normal cell by creating an abundance of abnormal proteins, which the immune system then recognizes and reads as a signal to destroy the tumor.

Whatever the explanation, Morris notes that using TMB as a biomarker could help clinicians predict the outcome of checkpoint inhibitor therapies.

Read full, original post: More Cancer Mutations, Better Immunotherapy Outcomes

Outbreak
Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Nigeriacotton

Video: We can ‘finally’ grow GMOs—Nigerian farmer explains why developing countries need biotech crops

Nigerian farmer Patience Koku discusses the GMO crop trials she is conducting on her farm, and why growers can "rise ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
breastfeeding bed x facebook x

Infographic: We know breastfeeding helps children. Now we know it helps mothers too

When a woman becomes pregnant, her risk of type 2 diabetes increases for the rest of her life, perhaps because ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...
favicon

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend