Video: Weaponizing CRISPR against superbugs

| | May 29, 2019
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Image: National Geographic
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Bladder infections, like many others, are increasingly becoming resistant to antibiotics.

“We are getting to the point where there are organisms that are resistant to every known antibiotic,” says Michael Priebe, a doctor who heads the spinal cord injury service at the VA medical center.

[So Priebe developed] a new kind of antibiotic made out of viruses that have been genetically modified using the gene-editing tool CRISPR.

Later this year, he and his colleagues plan to start infusing cocktails containing billions of phages genetically modified with CRISPR into patients like [spinal cord injury sufferer Alphonso] Evans twice a day for seven days at six centers around the United States.

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The study will involve 30 patients. Twenty of them will get the engineered phage cocktail, and 10 will get a placebo. The researchers will then follow the volunteers and conduct extensive tests of their blood and urine to see if the approach is safe and affects the levels of E. coli bacteria in their urinary tracts. If that’s the case, the company plans more research to see how well the approach might fight infections.

Read full, original post: Scientists Modify Viruses With CRISPR To Create New Weapon Against Superbugs

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