Menopause might be a tipping point for Alzheimer’s for millions of women

b de yhealt p
Credit: WSJ

Estrogen is the master regulator of metabolism in the youthful female brain, orchestrating everything from glucose transport and uptake to its breakdown for energy. [Researcher Lisa] Mosconi’s scans are rainbow-colored evidence that decreased levels of the hormone during menopause, which often starts when women are between the ages of 45 and 55, lead to a “bioenergetic brain crisis,” as she describes it. At some point during this seven-plus-year transition period, up to 60 percent of women experience what is known as menopause-related cognitive impairment: bouts of confusion, distractibility and forgetfulness.

A 2009 study found that newly postmenopausal women score just as well on cognitive tests as they did before the transition. Decades later, however, roughly a fifth of them will be diagnosed with Alzheimer’s disease. Mosconi and others believe that for many of the 3.6 million women living with the disease in the U.S. alone, menopause might have been a tipping point for cognitive decline.

Related article:  What makes human brain cells so powerful?


The menopause hypothesis—that decline in estrogen levels in this period renders the brain vulnerable to future damage—could offer answers. If Mosconi and other researchers are right, [the] millions of women worldwide who pass through this transition could benefit from lifestyle interventions and, conceivably but controversially, hormone therapy (HT) to prevent the disease.

Read the original post

Outbreak Daily Digest
Biotech Facts & Fallacies
Genetics Unzipped
Infographic: Deaths from COVID-19 are far higher than reported estimates

Infographic: Deaths from COVID-19 are far higher than reported estimates

More than 2.8 million people have lost their lives due to the pandemic, according to a Wall Street Journal analysis ...

Gilles-Éric Séralini: Activist professor and face of anti-GMO industry

The French biologist and his research team--funded by the Rodale ...
vandana shiva

Vandana Shiva: ‘Rock Star’ of GMO protest movement has anti-science history

In a 2012 interview, Bill Moyers referred to Vandana Shiva as ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend