CRISPR could help produce allergen-free soybeans. Here’s how it works

Print Friendly, PDF & Email

Food allergies occur when you eat …. and your immune system reacts to certain proteins in the food. Proteins that cause allergies are collectively called allergens, and more than 10 types of allergens are known in soybeans …. If mutations occur [in soy DNA], soybeans will not be able to produce allergen proteins. [Lecturer Tetsuya] Yamada’s goal is to mutate genes by editing the genome.

CRISPR / Cas9 is a two-part complex consisting of a guide RNA and a Cas9 protein, where the guide RNA targets a specific sequence of DNA and Cas9 actually cuts it.

The DNA sequence at the cut site is immediately repaired by the repair mechanism of soybean, but in rare cases, an error occurs when the sequence is deleted or the sequence is replaced with another sequence. This error becomes a mutation that prevents the allergen protein from being produced in soybeans.

Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

However, CRISPR / Cas9 is not a magical tool that allows you to edit DNA as you wish in an instant. Mr. Yamada succeeded in developing low-allergen soybeans with two soybean varieties “Enrei” and “Kariyutaka,” and published a paper summarizing the research results in 2020, but behind that is a two-year experiment. 

Editor’s note: This article was originally published in Japanese and has been translated and edited for clarity.

Read the original post

Outbreak Daily Digest
Biotech Facts & Fallacies
GLP Podcasts
Infographic: Trending green and going great — Every state in the US seeing decreased cases of COVID

Infographic: Trending green and going great — Every state in the US seeing decreased cases of COVID

The U.S. averaged fewer than 40,000 new cases per day over the past week. That’s a 21% improvement over the ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

* indicates required
Email Lists