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Human sexuality, of course, is made up of several components, though they overlap.
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But does testosterone play a role in the development of human sexuality? Testosterone acts on the brain (and other organs) by activating a complex protein, the androgen receptor. If a mutation in the latter occurs, the brain may not respond to testosterone: It’s as if it didn’t exist.
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Recent experimental evidence also points to real differences in male and female rodent brains…The hypothalamus of female rodents has greater levels of methylation than males: that is, more genes are suppressed. Giving such females testosterone post-natally reduces this: in other words, some of the methylation markers are removed, releasing those genes to become active. Such females behave more like males. Furthermore, giving a drug to little males that prevents de-methylation results in them behaving more like females.
[Read the full study here]
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