Canadian prostate cancer researchers have discovered the genetic fingerprint that explains why up to 30 percent of men with potentially curable localized prostate cancer develop aggressive disease that spreads following radiotherapy or surgery.
The findings…could help clinicians personalize effective, targeted therapies from the moment of diagnosis, says co-principal investigator Robert Bristow, clinician-scientist at the Princess Margaret Cancer Centre, University Health Network.
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“We used specialized state-of-the-art DNA sequencing techniques to focus on the genetics of prostate cancers to better understand what is so different from one man’s disease to another man’s disease,” says Dr. Bristow.
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“These genetic fingerprints had high accuracy in being able to discern those men who do well with surgery or radiotherapy and those men that already have early spread of their disease outside the prostate gland. This information gives us new precision about the treatment response of men with prostate cancer, and important clues as to how to better treat one set of men versus the other to improve cure rates overall.”
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