Siberian discovery could bring scientists closer to cloning Woolly Mammoth

The key to cloning a woolly mammoth may be locked into the Siberian permafrost.

At least, that’s what scientists in the blustery Russian tundra are hoping. An international team from Russia’s North-Eastern Federal University recently found well-preserved remains, including some fur and bone marrow, during a paleontological research trip in the northeastern province of Yakutia.

Russian newspaper Vzglyad talked to expedition leader Semyon Grigoriev, a North-Eastern Federal University professor, who said that the remains may still contain living cells, which would be vital to any cloning attempt. Previously-found clumps of woolly mammoth hair have allowed scientists to determine much of the extinct species’ genetic code, but have fielded no living cells.

Using race in medicine

race and ethnicity

Racial categories are currently ubiquitous in medicine and medical research. How are these categories determined? Is there uniformity from one study to another?

Additional Resources:

View the original article here: Using race in medicine

 

Genomic studies find all humans did not originate in East Africa

green africa

The largest study of genetic variance across present-day populations in southern Africa suggests that there is no single place in Africa from which all modern humans emerged. Instead, our species is the result of mixing between numerous early human populations across a vast area.

View the original article here: Genomic studies find all humans did not originate in East Africa

What does the $1000 genome mean for you?

DNA pretty

The cost of genome sequencing is starting to sink into the affordable range. Should you save up and get one? Can it really tell you anything meaningful at all? Who is going to sift through all the information your genome represents — and how will they do it? Science Online NYC (SoNYC) in cooperation with nature.com and Ars Technica and hosted at Rockefeller University presented and organized this roundtable discussion.

Additional Resources:

View the original article here: What does the $1000 genome mean for you?

Health and safety of GM foods

gmo brown

The battle lines are firming in the debate between the mainstream science community and anti-GM activists about the safety and health of GM foods. The latest salvo came from France, where a team led by Greenpeace-funded scientist Gilles-Eric Seralini of the University of Caen said they found that rats fed a diet containing a seed variety made tolerant to the spraying of Monsanto’s Roundup developed tumors died earlier than those on a standard diet. Curiously, and unusually, the researchers refused to pre-release their study to science journalists, so the initial reports presented a varnished version of the results. But within hours, a slew of scientists—almost all with no industry connections and many supportive of labeling of GM foods, savaged the study, as we reported in the Genetic Literacy Project.

“This study appears to be without scientific merit,” said Dr. Martina Newell-McGloughlin, director of the International Biotechnology Program at the University of California/Davis. “The problem here appears to be with the experimental design,” she said. “Whether it was deliberately devised to attain the desired outcome remains to be seen.”

The study claimed that rats fed a steady diet of feed made from biotech corn developed tumors.  In addition, the drinking water of the rats was continuously spiked with glyphosate, the active ingredient in many broad spectrum herbicide products. Glyphosate has a long history of safe use in more than 130 countries around the world and favorable environmental characteristics. It binds tightly to most soils making it unlikely to move to groundwater and degrades over time in soil and natural waters.

Scientists pointed out that numerous studies in the scientific literature attest to the fact that the particular stock of rats used in the study, lab animals known as the “Sprague-Dawley” type, are prone to develop tumors before the age of two. The Seralini study ran for about two years.

Seralini touted the study as the first long-term feeding study ever conducted, but Dr. Newell-McGloughlin pointed out that in fact the results of numerous long-term studies have been published with none of the results claimed by Seralini.

“These studies have been carried out using rats and other animals by scientific researchers from all over the world,” she said. “No unexpected adverse effect has been reported.”

Seralini, the lead author, responded in kind, one sympathetic scientist defended the study and anti-GM groups jumped to Seralini’s defense, demanding that the European Union suspend all similar GM foods and halt all further GMO approvals. French government officials, who are no friends of GM technology, asked the country’s health agency to investigate the findings further and appealed to European authorities to “take all necessary measures to protect human health,” including consideration of an emergency suspension of imports of the maize variety in Europe. The European Food Safety Authority, which previously reviewed similar research by Seralini and found it questionable, said it would examine the new study in detail.

 

Genetic screens—what’s the prognosis?

Sequencing the whole genome could provide a medical early warning on a previously unknown scale – but could it also bring dilemmas?

The price for whole genome sequencing is dropping sharply and is now under $1000—the issue discussed in the Science Online NYC/Nature.com/Ars Technica roundtable recently held in NYC . A few years ago, only a handful of labs had access to sequencing technology, but now such technology is almost ubiquitous. The $1,000 genome, while it has been talked about for a long time, will simply be a point on the way to a $100 genome or a $10 genome, “and finally to the point where the value of the information generated is far more important, scientifically and commercially, than the cost of generation.

Why should we have our genome unzipped? We might want to be part of a research trial. But more than likely, we’d do for medical reasons and in many cases with the backing of our medical provider: to help us understand our genetic vulnerabilities or as part of pre-natal or fetal screening. Will cheaper sequencing technology affect public health and what we could learn about diseases to help the sick? There will be challenges in sorting out the utility of genomic sequencing and figuring out who should be doing it—informed consent, storage of genomic data, what to do about incidental findings and preventing genetic discrimination. Despite these hurdles, it’s clear that cheaper sequencing will be useful for a number of reasons.

That moment is almost here. According to New Scientist’s Harriet Washington, separate research teams at Stanford University and the University of Washington in Seattle announced new techniques that enables the construction of a genetic “blueprint” of the developing fetus from as early as the first trimester that could be ready for mass use as early as 2017. In many ways, it would be welcome news, as it would avoid the 2% risk of miscarriage posed by today’s most common antenatal genetic tests, amniocentesis and chorionic villus sampling.

But the real world impact of such tests are complicated to figure out. Today, only around 5 per cent of women who have prenatal tests receive bad news. Full genome screens will detect many more problems – and will introduce much more uncertainty because whole-genome mapping predicts the mere possibility of disease. Not all genetic anomalies are expressed as pathology.

As the New York Time’s Gina Kolata noted in her excellent report on this thorny issue, The question of how, when and whether to return genetic results to study subjects or their families is one of the great current challenges in clinical research. Stay tuned.

 

 

 

 

Prenatal genome sequencing expected to pose challenges to doctors

Geneticists soon will be able to identify an unborn child’s risk of developing chronic diseases later in life and possibly shed light on other traits, such as athletic ability and intelligence, medical experts say.

The source of such information probably will be the expectant mother’s blood sample. For the first time, researchers recently extracted fetal DNA from a pregnant woman’s blood and examined the unborn baby’s genome.

View the original article here: Prenatal genome sequencing expected to pose challenges to doctors

Scientists use genetics, climate reconstructions to track global spread of modern humans out of Africa

Research indicates the out-of-Africa spread of humans was dictated by the appearance of favourable climatic windows. By integrating genetics with high resolution historical climate reconstructions, scientists have been able to predict the timing and routes taken by modern humans during their expansion out of Africa. Their research reveals that the spread of humans out of Africa was dictated by climate, with their entry into Europe possibly delayed by competition with Neanderthals. The research is published today, 17 September, in the journal PNAS. Dr Anders Eriksson, from the University of Cambridge, the lead author of the paper said: “By combining extensive genetic information with climate and vegetation models, we were able to build the most detailed reconstruction of human history so far.”

Growing better poplars for biofuels

It took mankind millennia of painstaking trial and error to breed hardier, healthier food crops.
 
“We can’t wait that long to develop better crops for biofuels,” says Victor Busov, a plant geneticist at Michigan Technological University’s School of Forest Resources and Environmental Science. “We need to move faster to meet the needs of tomorrow, and the only way we can do that is through knowledge.”
 
So Busov is using some 21st century tools—the genome of the poplar tree and snippets of DNA known as activation tags—to identify the genes that make plants grow faster or change their chemical or physical properties. He recently received a $1.1 million grant from the US Departments of Energy and Agriculture to analyze the genetic traits that affect the quality and yield of woody biomass from Populus, a species that includes poplar trees like aspens and cottonwoods. Michigan Tech will work with the Oak Ridge National Laboratory (ORNL) and the National Renewable Energy Laboratory (NREL) on the 3-year study.

View the original article here: Growing better poplars for biofuels – Phys.Org

Kenya emerges as hub for bio-tech in east African region

Kenya has emerged as a leader in the development and use of biotechnology in the east and central African region. It was among the first African nations to embrace the use of biotechnology, especially in the agriculture sector.

As a result, other east African nations come to Kenya to learn from its experiences. Even its economic blue print, Vision 2030 recognizes the role of biotechnology in propelling the nation to middle income status. Currently there are a number of biotechnology projects in progress by both public and private research institutions.

International Service for the Acquisition of Agri-Biotech Applications (ISAAA) AfriCenter Director Dr. Margaret Karembu told Xinhua in a recent interview in Nairobi that at least five agricultural crops are currently undergoing biotechnology improvements in Kenya.

View the original article here: Kenya emerges as hub for bio-tech in east African region – Coastweek

The Bushmen tell us a lot about human evolution and genetics

When it comes to the human genetics of the Khoe-San there’s a little that’s stale and unoriginal for me in terms of presentation. The elements are always composed the same. The Bushmen are the “most ancient” humans, who can tell us something about “our past,” about “our evolution.” Tried & tested banalities just bubble forth unbidden. I have no idea why. There’s a new paper in Science on the genetics of the Khoe-San, which includes Bushmen, which brought to mind this issue for me because of the outrageous nature of the press releases.

The title of the paper itself is a testament to vanilla, Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History. This is absolutely not surprising. Are you shocked that the Khoe-San have adaptations? Or that African history is complex? The wonder of it all! This paper actually revisits much of the same ground as Pickrell et al.’s originally titled The genetic prehistory of southern Africa. Before Dr. Pickrell executes throw-down on me on Twitter let me concede that I have no creative ideas to offer in terms of an alternative title. Rather, I have an idea: perhaps in the future scientists could explore the evolutionary genetic basis for steatopygia? The trait is not limited just to Khoe-San, my distant cousins the Andaman Islanders also exhibit it. Perhaps this is the ancestral state of the human lineage? This is a situation where the titles just write themselves!

View the original article here: The Bushmen tell us a lot about human evolution and genetics

First human whole-brain genetic map created

A team at the Allen Institute for Brain Science has created the first human brain-wide map of gene expression data.

The achievement marks a major milestone for the Allen Institute, which previously had released similar data sets for the mouse brain. The data set will allow scientists to test new hypotheses about how the particular genetic codes of different brain areas lead to the unfathomably complex, unified organ.

The task of creating an atlas of human gene expression in the brain is not an easy one. First, acquiring clinically normal brains can be a drag — brains can be among the hardest organs to get permission to excise, and to chop up for study.

Once a sample is available, the scientists need to be extremely precise with how they partition the brain so they can reliably connect genes to regions. One wrong cut and the data become imperfect.

View the original article here: First human whole-brain genetic map created

Diseases of aging map to a few ‘hotspots’ on the human genome

Researchers have long known that individual diseases are associated with genes in specific locations of the genome. Genetics researchers at the University of North Carolina at Chapel Hill now have shown definitively that a small number of places in the human genome are associated with a large number and variety of diseases. In particular, several diseases of aging are associated with a locus which is more famous for its role in preventing cancer.

View the original article here: Diseases of aging map to a few ‘hotspots’ on the human genome

As corn withers, biotech companies focus on drought-tolerant crops

The worst U.S. drought in half a century is withering the nation’s corn crop, but it’s a fertile opportunity for makers of genetically modified crops.

Agricultural biotechnology companies have been pouring hundreds of millions of dollars into developing plants that can withstand the effects of a prolonged dry spell. Monsanto Co., based in St. Louis, has received regulatory approval for DroughtGard, a corn variety that contains the first genetically modified trait for drought resistance.

View the original article here: As corn withers, biotech companies focus on drought-tolerant crops – Bend Bulletin

Scientists savage study purportedly showing health dangers of Monsanto’s GM corn

corn husks

Are GM foods harmful or nutritionally less beneficial when compared to conventional or organic foods? Scientists and regulators almost universally say “no.” That’s why a study published this week claiming that GM corn causes cancer in rats is creating such a furor. What’s the story behind the story? Jon Entine, executive director of the Genetic Literacy Project, reports.

Does Monsanto’s Roundup Ready corn (Europeans call it maize) cause health problems? It’s a reasonable question. It’s been asked and answered, at least to the satisfaction of most researchers.

View the original article here: Scientists savage study purportedly showing health dangers of Monsanto’s genetically modified corn

Prop. 37: Another example of the perils of the initiative process?

prop label

Love it or hate it, the one thing you can say for sure about California’s ballot initiative process is that it’s the absolute worst way to craft policy dealing with complex scientific issues.

That doesn’t stop advocates on one side or another from constantly trying, with the result that the public’s understanding of the underlying facts plummets faster than you can say, well, “Proposition 37.”

Proposition 37 is on November’s ballot. The measure would require some, but not all, food sold in California and produced via genetic engineering to be labeled as such. (There are exemptions for milk, restaurant food and other products.)

Genetic engineering, or genetic modification, which involves manipulating DNA or transferring it from one species to another, is increasingly common in agriculture and food processing, and wouldn’t be banned or even regulated by the measure. Genetic engineering has pluses and minuses. It can increase crop yields and pest resistance. But it can also affect the environment in negative ways — pollen or seeds from genetically engineered crops can be spread by wind, birds or insects to territory where they’re unwanted, for example.

View the original article here: Prop. 37: Another example of the perils of the initiative process?

Genetic Information Nondiscrimination Act passes House of Representatives

The House of Representatives passed the Genetic Information Nondiscrimination Act (GINA) of 2007 on Wednesday, April 25. GINA is expected to pass the Senate and be signed into law in the coming months.

Despite widespread, longstanding agreement among American citizens and politicians that protection from genetic discrimination should be clear and consistent, individuals’ genetic information has, to this point, been protected only by a largely untested patchwork of state and federal regulations. Ninety-two percent of Americans are concerned that results of a genetic test that tells a patient whether he or she is at increased risk for a disease like cancer could be used in ways that are harmful to the person, and most believe that employers and health insurers should not have access to this information.

View the original article here: Genetic Information Nondiscrimination Act Passes House, USA …

Cord blood-derived stem cells: New therapeutic option for brain disorders?

ae x

Stem cell technology has the potential to revolutionize medicine, but the revolution has been considerably slower than expected. Government restrictions and ethical dilemmas have put up roadblocks to fast-paced biological research, and even when these roadblocks are absent, controlling the behavior of stem cells (cells that have the ability to form a number of cell types and tissues) in a petri dish has proved tricky to say the least.

In one particular area of stem cell research, however, progress has been steady. Cord blood stem cells can be harvested from the umbilical cord and placenta of a newborn baby and stored for future use, the idea being that they can be used down the road should that baby (or a genetically similar relative) become sick. These stem cells have been used to treat close to 100 blood-based conditions, including several types of leukemia.

View the original article here: Cord Blood-Derived Stem Cells – a New Therapeutic Option for Brain Disorders? – Brain Blogger (blog)

glp menu logo outlined

Newsletter Subscription

* indicates required
Email Lists