Stem cell scientist outlines his top five challeges for embryonic stem cell nuclear transfer

It was intriguing last week to read about another advance in somatic cell nuclear transfer (SCNT)-based therapeutic cloning of human embryonic stem cells (hESC). The first such work was published last year by Mitalipov’s group from OHSU.

This second paper to produce so-called nuclear transfer hESC (NT-hESC) made the important advance to show that it could be done using adult and even old human somatic cells. This is a reproducible technology, which is very important.

However, key challenges and concerns remain for human therapeutic cloning and for potential clinical application of NT-hESC. Below is my list of the top 5 challenges.

  • NT-hESC must be indisputably better than human iPS cells and IVF hESCs to be relevant clinically.
  • The head start of other human pluripotent stem cells.
  • Human egg procurement challenges.

 

Read the full, original story: Top 5 challenges for SCNT cloned human embryonic stem cells

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