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UK considers benefits and risks of ‘three-parent’ IVF

This article or excerpt is included in the GLP’s daily curated selection of ideologically diverse news, opinion and analysis of biotechnology innovation.

The UK Parliament will soon consider making Britain the first country to allow three person IVF. The regulations are yet to be approved, but the government is currently backing moves to allow the creation of babies with DNA from three people in cases where the children are at risk of inheriting mitochondrial disease.

Objections have been raised, however, and it’s important to consider the ethical arguments for and against allowing this new procedure.

Mitochondria generate energy for our cells and have been compared to batteries or power stations. When people suffer from mitochondrial disease, their mitochondria don’t produce enough energy to make their cells work properly. The disease takes many forms but often affects important body parts such as the brain, liver or heart. Some mitochondrial disease is fatal and, at present, there’s no effective cure.

Mitochondrial replacement is proposed, not as a treatment for existing sufferers, but as a way of helping “at risk” parents avoid passing it on to their children. One technique (Maternal Spindle Transfer) involves removing damaged mitochondria from the mother’s egg and replacing them with healthy mitochondria from a donated egg.

As with any novel treatment, there are questions about safety and efficacy, but mitochondrial replacement also raises ethical concerns that go beyond the usual assessment of risks and benefits.

Read the full, original story: The ethics of three person IVF


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