Researchers track cell development using CRISPR

crispr

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis.

Alexander Schier simply wanted to make sure he destroyed a gene in zebrafish embryos, so he turned to the genome-editing system known as CRISPR. But Schier, a developmental biologist at Harvard University, ended up doing more than knocking out a gene. He and colleagues devised a new way to mark and trace cells in a developing animal. In its first test, described in Science, the researchers used CRISPR-induced mutations to reveal a surprise: Many tissues and organs in adult zebrafish form from just a few embryonic cells.

Schier and his colleagues took advantage of what Harvard geneticist George Church calls CRISPR’s “genome vandalism.” In normal CRISPR editing, a so-called guide RNA precisely targets the enzyme Cas9 to a particular site in the genome so that it can break the double-stranded DNA there. In one of CRISPR’s original uses, a template DNA tells the cell’s machinery how to repair the double-stranded break, allowing edits as precise as the changing of a single nucleotide.

Read full, original post: Genome editor CRISPR helps trace growth of embryos – and maybe cancer next

ADVERTISEMENT
Outbreak Daily Digest
Biotech Facts & Fallacies
GLP Podcasts
Infographic: Here’s where GM crops are grown around the world today

Infographic: Here’s where GM crops are grown around the world today

Do you know where biotech crops are grown in the world? This updated ISAAA infographics show where biotech crops were ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

* indicates required
Email Lists
Send this to a friend