Adrian Dubock, Golden Rice scientist: Greenpeace, GMO critics misrepresent humanitarian project

The debate over Golden Rice has heated up again, this time in response to the call from 107 Nobel prize winners (of the 296 living laureates) for Greenpeace to cease campaigning against the nutritionally enhanced crop that its supporters say could reduce Vitamin-A deficiencies causing blindness and death in children in the developing world. The laureates went so far as to question if the NGO's behavior should be considered "crimes against humanity".

Greenpeace International's website states that the release of GMOs into the natural world is a form of "genetic pollution." Wilhelmina Pelegrina of Greenpeace Southeast Asia Golden Rice defended the non profit, firing back in a statement on June 30, stating, “Accusations that anyone is blocking genetically engineered ‘Golden’ rice are false." She then shifted the blame, claiming:

Corporations are overhyping ‘Golden’ rice to pave the way for global approval of other more profitable genetically engineered crops. This costly experiment has failed to produce results for the last 20 years and diverted attention from methods that already work. Rather than invest in this overpriced public relations exercise, we need to address malnutrition through a more diverse diet, equitable access to food and eco-agriculture.

Golden Rice, an Asian rice variety genetically modified to synthesize beta carotene which is a precursor to Vitamin A has been in development for decades, but is still not yet available to farmers for a variety of reasons. Washington University anthropologist Glenn Davis Stone and Dominic Glover of the University of Sussex offered their view of why the rice is not yet on the market in a recent peer-reviewed paper. Stone subsequently made headlines when, in a public relations interview for Washington University promoting his article, he echoed Greenpeace's long held assertion that activists are not responsible for the crop's delay: "...we find little support for the common claim that environmental activists are responsible for stalling its introduction. GMO opponents have not been the problem."

Stone and Glover, both long-time skeptics of the benefits of crop biotechnology, cite in their journal article research by Adrian Dubock, who has served as the project manager for the Golden Rice project since 2008 and is the executive secretary of the Golden Rice Humanitarian Board since 2010. In a letter sent exclusively to the Genetic Literacy Project, Dubock takes issue with the paper and Stone's comments, which he believes misrepresented his work, the progress of Golden Rice, and the motives of those working on the project.

 


Adrian Dubock, Executive Secretary, Golden Rice Humanitarian Board, in response to:

"Disembedding Grain: Golden Rice, The Green Revolution, and Heirloom Seeds in the Philippines,"GD Stone & D Glover Published 16 April 2016. In Agriculture and Human Values, The Journal of the Agriculture, Food and Human Values Society, Volume 33, Issue 1

“Let food be thy medicine and medicine be thy food.” Hippocrates

When I was a child in the 1950’s my family didn’t have a TV. But I did see TV in a neighbor's house. One of the abiding images is of Indian’s in loin cloths standing in line for food handouts: 50% of India has wheat as the staple crop and 50% has rice as the staple crop, and the country was not able to produce enough to feed its population.

Stone & Glover are critical of the “Green Revolution”, although the Nobel Prize Committee thought differently when they awarded the Nobel Peace Prize to Normal Borlaug in 1970. Some people thought that Gurdev Khush should have been awarded it too: at the relevant time he was the chief Rice Breeder at the International Rice Research Institute. Gurdev Khush has received many accolades, including the World Food Prize, awarded annually and funded in part by the endowment provided from the Nobel Prize money of Normal Borlaug. Here is what Dr. Khush reported in April 2015 on Indian Rice yields:

The Green Revolution had a remarkable impact on food security in India. During the 1960s, India imported up to 10 million tons of food grains per year. For the past 10 years,India has exported 4 to 6 million tons of food grains every year. The quantity of rice exported in 2013-14 was 10.7 million tons—more than any other country. Considering that the population of India has increased from 350 million in 1960 to 1.3 billion at present, this is a remarkable achievement.The present food grain situation in the country is the result of the unprecedented increase in rice and wheat production because of wide-scale adoption of Green Revolution technology. For example, wheat production increased from 10.3 million tons in 1960 to 97 million tons in 2013-14. Rice production increased from 34.6 million tons in 1960 to 154 million tons in 2013-14.

Nobody forced Indian rice farmers to buy the improved seeds sustainably over so many rice generations, and I don’t expect the previously hungry of India much care that the rice varieties were not embedded in “the cultural, historic, agronomic, economic and public health contexts” specific to India, which Stone and Glover, clearly serious scientists in their fields of anthropology and environmental studies, think are so important. I don’t expect they much cared either that, as noted by Stone & Glover: The Green Revolution spread generic, disembedded high input seeds to replace locally adapted landraces as well as peasant attitudes and practices associated with them.” After all, despite the green revolution there are still somewhere above 20,000 varieties of rice for farmers, including ‘peasant’ farmers, to choose to plant.

Glover & Stone also ignore some important Principles of the 1992 UN Biodiversity Convention. Annex 1 states:

Principle 1

Human beings are at the centre of concerns for sustainable development.

They are entitled to a healthy and productive life in harmony with nature.

Also relevant are:

Principle 4

In order to achieve sustainable development, environmental protection shall constitute an integral part of the development process and cannot be considered in isolation from it.

Principle 5

All States and all people shall cooperate in the essential task of eradicating poverty as an indispensable requirement for sustainable development, in order to decrease the disparities in standards of living and better meet the needs of the majority of the people of the world.

Increasing a country's self-sufficiency in macronutrients is surely a key part of the above, and more important than the considerations promoted by Stone & Glover.

In both cases, wheat and rice production, when Indian’s had enough to eat of either staple, they received carbohydrates – excellent as source of energy, but essentially no micronutrients – minerals and vitamins – essential for human health.

It is the frequent lack of a source of vitamin A in the diet of poor people for whom rice is the staple which was at the forefront of Golden Rice inventor’s Peter Beyer and Ingo Potrykus attention during their quest to invent Golden Rice. And once 'proof of concept' Golden Rice was achieved in 1999, it was the plight of the poor, in India in particular, which caused them to insist that India be included in the humanitarian, not-for-profit Golden Rice project, whether or not India was listed as a “Developing Country” by FAO. As has been reported by Semba (2012):

With nearly two million under-five child deaths per year, India ranks at the top of all nations' under-five mortality………… India's share of global under-five deaths is rivaled only by that of sub-Saharan Africa…. Compared with its immediate neighbors, India has made relatively little progress in mitigating child mortality since 1980.”The low coverage of India's vitamin A supplementation program may account for that country's relative failure in reducing child mortality…….What has made the vitamin A deficiency situation in India so intractable? The probable answer is lack of national leadership in public health and nutrition, leading to inadequate coverage in vitamin A supplementation. There is a close correlation between high vitamin A deficiency, high under-five mortality, and deep poverty. Sadly, this confluence of ills describes much of India.

It is remarkable, that Stone & Glover, despite over 100 references to their paper (including one of mine from 2014) and 13 individuals acknowledged—didn’t think to contact either of the inventors or myself for a perspective, or follow up on two other papers of mine referenced in the one they did read: Golden Rice: a long-running story at the watershed of the GM debate and The politics of Golden Rice.

A main part of the thesis of Glover & Stone is that Golden Rice is disembedded from “the cultural, historic, agronomic, economic and public health contexts specific to the Philippines”. Except for a brief footnote implying that Golden Rice research in ‘Vietnam, India and Bangladesh’ is unworthy of discussion, they state that because the Philippines is the home to the International Rice Research Institute (IRRI), that the work of IRRI (which was Potrykus and Beyer’s first – of 15 – rice research institute licensees, all the rest of which are national public sector labs) is only designed to benefit Philippine consumers. This is incorrect.

Perhaps it is because they are unwilling to acknowledge that due to technology limitations it was not possible to directly transform into indica rices, that this deceit continues thought their paper. As is clear from Dubock 2013, one of the papers they don’t refer to:

Golden Rice seed is available to public-sector rice-breeding institutions in less developed countries where rice is the staple and vitamin A deficiency endemic. Supply is subject only to national and international regulations, and simple and free agreements. Then using conventional breeding techniques the nutritional trait can be introduced into any locally adapted and preferred variety of rice so that its agronomy, preparation and taste will be the same. Farmers will subsequently, initially using seed from their national seed supply system, be free to plant, harvest, save seed, and locally sell Golden Rice as they wish. There is no reason Golden Rice should cost any more than white rice to the farmer or consumer, and consumer benefit is expected from its health-promoting properties. [Emphasis added].

Thus with respect to locally adapted and preferred rice varieties the Golden Rice nutritional trait can be embedded in the cultural, historic, agronomic, economic and public health contexts of each country, and in any variety or rice preferred there – which of course may not be the “heirloom seeds” apparently preferred for all purposes by Stone & Glover: but surely the seed variety should be for local rice breeders to select, not foreigners, whatever their specialization and motivation? Local choices of rice variety are exactly what is promoted by the Golden Rice project.

From Dubock 2014, the other paper they choose to ignore, it is clear how the suspicion of GMO-crops induced by an out of date Cartagena Protocol has been harvested by anti-globalization-anti-gmo-activists for fund raising and cynically by the organic food industry also to further their commercial claims. This paper also explains the difficulties put in the way of researchers in terms of international collaboration through moving gmo-crop samples: all incidentally in contravention of the key principles of the Convention on Biodiversity, a few of which are quoted above, and where the ‘Precautionary Principle’, the primary objective of the Cartagena Protocol is only Principle 15 of 27. As reported in the Dubock 2014 paper they refer to (page 80):

As of today, October, 2011, more than two and a half years on [from the March 2009 Lead Event decision], the selected Golden Rice seed has been supplied to research institutes in only two countries: India and Philippines. The inventors and the public sector Golden Rice licensees in other countries are very frustrated by this slow progress, at a time when multiple rice breeding programmes could be underway in multiple countries. All licensees already have the legal ownership of the Golden Rice trait. They need the physical materials. And use of the same physical materials—the same transformation event even in different varieties of rice—is effectively mandated by the regulatory environment.

This frustration that so few of the rice breeding resources, apart from IRRI, of the public sector in all licensee nations have been harnessed in developing Golden Rice is still current. (Many of the reasons are summarized in Dubock 2014.)

Glover and Stone are politely rude about the motivations of those involved with Golden Rice. It is untrue that Golden Rice has been for “15 years ….a public relations vehicle”, and those involved are not responsible for how others refer to the project. They mention that the Tang et al 2012 study of the bioconversion of the beta-carotene in Golden Rice was retracted. They don’t mention the published conclusions of the Tufts University investigation that preceded the retraction that

These multiple reviews found no concerns related to the integrity of the study data, the accuracy of the research results or the safety of the research subjects. In fact, the study indicated that a single serving of the test product, Golden Rice, could provide greater than 50 percent of the recommended daily intake of vitamin A in these children, which could significantly improve health outcomes if adopted as a dietary regimen.

They question whether the beta carotene in Golden Rice degrades on storage or in cooking. Both points are explained in the papers I have referred to, and are relatively insignificant. Here is a photo of three samples of Golden Rice stored at ambient temperature since harvest:

Screenshot 2016-06-30 at 11.43.11 AM

The photo was taken in October 2015, and has not been ‘photo-shopped’. Most resource poor farmers do not store rice for very long because they are short of food. Yet here rice harvested in March 2011 still contains beta-carotene – probably at useful levels indicated by the color 4 ½ years after harvest.

As explained in the 2014 paper of mine Stone & Glover do quote:

Dr Parminder Virk, IRRI rice breeder in charge of the programme, [in 2009] presented comprehensive data [including the slide reproduced below] ……… covering ten agronomic measurements used by rice breeders as well as carotenoid content and degradation over time” for Golden Rice, and “Carotenoid content degrades rapidly after harvest (as is common in all crops) but in rice the rate of decrease after 2 months was demonstrated to be minimal.” And “All calculations (and subsequent breeding decisions) used only the retained β-carotene content after 2 months of storage. Calculations also assumed 20% losses of carotenoid through cooking, although only 6% losses had been noted….

It seems that Stone and Glover were remiss in not referring to these facts whilst referring to questions about these matters raised by Pénicaud et al (2011), and Michael Hansen (2013).

And this graph is available on the web with a little searching (it’s in a PowerPoint presentation of mine):

Screenshot 2016-06-30 at 11.59.33 AMThere are so many other aspects of Glover and Stone’s analysis of Golden Rice which are selectively chosen to further their thesis, that is brings into doubt their assertion that “we do not champion or disparage the forms of embeddedness or disembeddedness we have described in the three rice worlds. [Golden Rice, The Green Revolution, and heirloom seeds in the Philippines].”They offer advantages and disadvantages, depending on one’s perspective and purpose."

So let’s look at the perspectives of Golden Rice’s inventors and donors, Professors Potrykus and Beyer, The Golden Rice Humanitarian Board, and all the rice institutions and their Governments who have been investing in the project for so long.

Vitamin A deficiency (VAD) remains a killer in many parts of the developing world. And rice feeds half the world every day. Rice has to be polished for storage or it goes rancid, and polished rice contains no pro-vitamin A. There is no new data on the mortality reducing impact of providing a source of vitamin A to those that need it, as the positive effects are so clear in a research context that to withhold it would be unethical. And only Random Controlled Trials can and have isolated the one cause which relates to mortality: such data have demonstrated the 23 – 34% of global under 5 years child mortality can be prevented by an accessible source of vitamin A. (As well as a lot of blindness prevented. But most who die from VAD induced impaired immune response do so before becoming blind.)

The <5y child global mortality figures from the UN are:

Screenshot 2016-06-30 at 12.02.07 PM

Important Millennium Development Goals: 1, to eradicate extreme poverty and hunger, and Goals 4 to “Reduce by two thirds, between 1990 and 2015, the under-five mortality rate”, & 5, to reduce significantly maternal mortality, all between 1990 and 2015, despite significant progress, were not met.

And, despite all current knowledge and interventions, the latest data on VAD deaths, mostly children, are as follows:

Notes: * Mostly children <5 years; ** 1 in 3 HIV deaths is due to TB; *** mortality from TB of HIV negative people. Data sources: For 2010 data: Dubock 2013; for 2014 data: UNICEF 2016, West et al. 2010, UNAIDS 2015, WHO 2014a, b.
Notes: * Mostly children Data sources: For 2010 data: Dubock 2013; for 2014 data: UNICEF 2016, West et al. 2010, UNAIDS 2015, WHO 2014a, b.

For more than a quarter of a century, vitamin A deficiency (VAD) has been recognized by the United Nations as a significant public health problem. Key milestones included the:

1.) 1990 UN World Summit for Children, where 50 heads of government and senior government officials committed their governments to the virtual elimination of VAD by the year 2000 (UNICEF, 1990).

2.) 1992 UN International Conference on Nutrition, which concluded that:

  • VAD control is the most cost-effective child health/survival strategy governments can pursue.
  • All sectors of society should support the virtual elimination of VAD.
  • Strategies should include promoting breast-feeding, dietary diversification, vitamin A supplementation and food fortification.
  • Locally available food-based strategies are the first priority. Vitamin A capsule supplementation is only an interim measure. (FAO, 1992)

3.) 2004 UNICEF and the Micronutrient Initiative Report ‘Vitamin and Mineral Deficiency’, which concluded that ‘controlling vitamin and mineral deficiency is an affordable opportunity to improve the lives of two billion people and strengthen the pulse of economic development’ and that ‘probably no other technology available today offers as large an opportunity to improve lives and accelerate development at such low cost’ (UNICEF, 2004).

In adults (in the USA) and most importantly children (in China), careful and sophisticated research has shown that the beta-carotene in Golden Rice, following only a single meal, is very efficiently converted to vitamin A by the human body. Only a few tens of grams of dry Golden Rice, when cooked and consumed daily, is expected to combat vitamin A deficiency and save life and sight. The results show that Golden Rice “may be as useful as a source of preformed vitamin A from vitamin A capsules, eggs, or milk to overcome vitamin A in rice-consuming populations”.

The inventors of Golden Rice, nor their public sector licensees, created the controversy which surrounds GMO-crops, nor have they stimulated the use of Golden Rice in pro-gmo-crop or anti-gmo-crop arguments. All understand that poverty is the principal cause of vitamin A deficiency. They know that the need for cheap and effective VAD interventions with a minimum requirement to adjust cultural practices of crop growth, processing, storage, food preparation or diet remains.

In this context it is hard to take Stone and Glover’s criticism of Golden Rice concerning “embeddedness” or “productivism” and “the cultural, historic, agronomic, economic and public health contexts” as a helpful contribution in the real world, despite the consideration that, because gmo-crops are controversial, Golden Rice may provide a platform for more discussion than normal, of their ideas.

And let’s remember Principle 1 of the Annex to the UN’s Convention on Biodiversity:

“Human beings are at the centre of concerns for sustainable development. They are entitled to a healthy and productive life in harmony with nature.”

Adrian Dubock is project manager for the Golden Rice project and the executive secretary of the Golden Rice Humanitarian Board. 

  • mem_somerville

    Thanks so much for writing a response to this. People have been using Stone & Glover as if it exonerated Greenpeace in some manner, when it absolutely did nothing of the sort.

  • Diana Pena

    Oh my goodness, i love this.

  • Jason

    Well, of course they misrepresent the project! If GMOs are actually seen feeding poor people their whole campaign goes That would cost them donations!

    • Rickinreallife

      Exactly. I suspect Greenpeace is more fearful golden rice will work than it fears it won’t work.

      • As far as I can gather, that’s always been their only fear.

  • Eric Bjerregaard

    Thanks much and best wishes for quick market penetration.

  • Stuart M.

    How can a “scientific” paper written by an anthropologist and an environmentalist possibly “prove” that Greenpeace had no role in preventing the adoption of Golden Rice? Hysterical opposition and mobilization of mobs to oppose a new technology had no effect? And that they attack the Green Revolution too for not being “embedded in the cultural, historic, agronomic, economic and public health contexts” specific to India is just too ridiculous. The cultural, historic, agronomic, economic and public health context of India in the 1960s was MASS HUNGER and STARVATION. The context of much of southeast Asia today is 100s of thousands of children going blind and dying from lack of vitamin A. Stone and Glover think this is normal and should be respected. They really make me sick. What I don’t understand is why Golden rice hasn’t progressed in spite of the hysterical opposition to it. Some have suggested poor Philippine farmers don’t care about nutritional properties of the rice, they only want to grow white, high yielding varieties that stand a chance in the marketplace. This again is a condemnation of Greenpeace which has totally disinformed the Philippine population about Golden Rice.

  • Guest

    Is there a reason Vitamin A supplements can’t do the job alone?

    • Eric Bjerregaard

      Yes, they are a temporary fix whose supply could be cut off by political instability or economic recessions. Best to have folks grow as much of this locally as possible

    • Stuart M.

      I have heard this for many years from shills for Greenpeace, “Just give them a pill.” Well, don’t just sit there, start organizing the effort, raise the money. Oh, you and Greenpeace didn’t mean that seriously? Oh darn, I guess pills just aren’t “embedded in the cultural, historic, agronomic, economic and public health contexts” of these people…

    • adrian

      Vitamin A capsules (VAC) have been distributed since the early 1990’s. They undoubtedly have saved millions of lives. But as the figures in the tables above indicate, there is a still a huge public health problem with vitamin A deficiency, which current interventions have not fixed. There are anyway some age limitations on how VAC’s can be practically used, and there is an ongoing cost associated with their use, which has to be paid for somewhere. Biofortification of staple crops, such as Golden Rice with provitamin-A, potentially provide sustainable cheap and effective additional interventions for major micronutrient deficiencies.

    • Rickinreallife

      It’s the difference between empowerment and dependency.

  • Keith

    The people developing the seed are looking for a profit, when they start givning the seed away I might start believeing their bull shit.

    • jmk

      What bullshit? IRRI has also developed hundreds of non-enriched rice varieties that farmers buy from seed producers

    • Guy G

      effectively speaking they are giving it away. The only price being charged is that for production, someone has to pay for the fuel to grow it and ship it. After that the traits are non patented and can be freely bred into local race lines. Your comment displays a delusional idea about how the world works.

    • adrian

      Keith, the creators – Professors Beyer and Potrykus, of the nutritional trait in Golden Rice have donated the trait for free of charge use in public sector owned rice varieties in developing countries by resource farmers. It is a license term agreed with the government agencies involved, that there will be no charge for the trait, which will cost the same as white rice. No individual nor organisation involved with the development of Golden Rice has any financial interest in its adoption. This is a humanitarian effort!

  • Alexander Paulsen

    Why would you spend hundreds of millions of dollars to create this when for a tiny fraction of that you can teach farmers to grow high beta carotene vegetables in the berms along the rice fields or provide supplement tablets for .00001% of the total cost!
    Malnutrition is way beyond one single nutrient

    • Farmer with a Dell

      Why would we invest in a large project? Oh, I don’t know, unless maybe because putting something as fundamental and widely grown as rice into production will result in tens of billions of dollars worth of continuous food production that will correct and prevent hundreds of thousands of cases of vitamin A deficiency while you’re still screwing around planting and harvesting tiny odd lots of veggies totaling tens of dollars and distributing tablets at a cost of tens of millions of dollars after corrupt bureaucrats take their cuts to alleviate a few hundred instances of vitamin A deficiency. Maybe something like that?

      The sheer volume of acres with potential for golden rice production compared to the piddling square feet of berms that may be suitable for growing carrots or whatever should provide the intelligent person a clue to the respective quantities of beta carotene that could be routinely produced and consumed. Yep, it should be a pretty obvious clue. It must take a lot of conviction and relentless attention to ignoring detail for one to remain so wonderfully clueless.

    • Farmer with a Dell

      Why would we invest in a large project? Oh, I don’t know, unless maybe because putting something as fundamental and widely grown as rice into production will result in tens of billions of dollars worth of continuous food production that will correct and prevent hundreds of thousands of cases of vitamin A deficiency while you’re still screwing around planting and harvesting tiny odd lots of veggies totaling tens of dollars and distributing tablets at a cost of tens of millions of dollars after corrupt bureaucrats take their cuts to alleviate a few hundred instances of vitamin A deficiency. Maybe something like that?

      The sheer volume of acres with potential for golden rice production compared to the piddling square feet of berms that may be suitable for growing carrots or whatever should provide the intelligent person a clue to the respective quantities of beta carotene that could be routinely produced and consumed. Yep, it should be a pretty obvious clue. It must take a lot of conviction and relentless attention to ignoring detail for one to remain so wonderfully clueless.

    • Stuart M.

      Blind and dying children? Alexander and Greenpeace say, “LET THEM EAT CAKE!”

    • agscienceliterate

      You seem to have the answers. Propose that to the Indian government. See how that works out for ya.

    • I don’t know! Maybe, because it will cost a lot more to teach farmers to grow vegetables that are not easily available in their regions, than to simply provide them with a breed of rice, which they already know how to cultivate and is a staple of their diet? Ah also, providing supplement tablet requires a huge logistics that does cost a lot and will simply make them more dependant on governmental programs, probably run and financed by humanitarian NGO, as the government officials themselves are often so corrupt and not to be trusted. Or, are you saying we should change their way of life to make sure they never need to rely on GMO, is that it?

    • Pogo333

      Excellent First World solutions! And why can’t they just buy the appropriate vegetables at their neighborhood Super Walmart or Whole Foods? Those annoying resource-poor farmers in developing countries. Why can’t they just grow carrots?

      Rice grows in those areas and people are accustomed to eating it. Vegetables are much more difficult to produce than grains, and success with supplements would be dependent on external production and transport, and on the willingness and conscientiousness of the people in using them. All of these things combine to make use of vegetables and supplements unacceptable.

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