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Gene linked to Alzheimer’s may cause developmental disorders in children

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis.

The gene that makes some people more vulnerable to Alzheimer’s disease as adults also affects the brain development and mental abilities of children, a new study shows.

The findings…suggest that Alzheimer’s may be much more than a disease related to the brain’s inability to clear beta amyloid plaques. Instead, it may be useful to think of it as a developmental disorder.

The APOE gene tells cells how to make a protein called apolipoprotein E…The gene comes in three varieties, known as the e2, e3 and e4 variants…People with one — and especially two — e4 variants are significantly more likely to develop Alzheimer’s than people without e4.

The results “support the provocative idea that AD (Alzheimer’s disease) is, in part, a developmental disorder,” wrote brain researchers Rebecca Knickmeyer…and Dr. M. Elizabeth Ross[.]

If so, they wrote, it may be possible to develop treatments for children with high-risk DNA variants that would — decades later — delay the onset of Alzheimer’s, reduce its severity or prevent it altogether.

Read full, original post: Brain changes wrought by gene linked to Alzheimer’s may begin in childhood, scientists say

The GLP aggregated and excerpted this article to reflect the diversity of news, opinion, and analysis. Click the link above to read the full, original article.
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