Faulty wiring? Tracing damaged circuits linked to autism, schizophrenia


Neuroscientists today know a lot about how individual neurons operate but remarkably little about how large numbers of them work together to produce thoughts, feelings and behavior. What is needed is a wiring diagram for the brain—known as a connectome—to identify the circuits that underlie brain functions.

[I]n a paper published March 28 in Nature, an innovative brain-mapping technique developed at Cold Spring Harbor Laboratory (CSHL) has been used to trace the connections emanating from hundreds of neurons in the main visual area of the mouse cortex, the brain’s outer layer. The technique, which exploits the advancing speed and plummeting cost of genetic sequencing, is more efficient than current methods, allowing the team to produce a more detailed picture than previously possible at unprecedented speed.

Related article:  A single 'live' vaccine could fortify immune systems against measles and other diseases

The method, called MAPseq (Multiplexed Analysis of Projections by Sequencing), works by tagging cells with genetic “bar codes.”

One possibility is that the huge diversity of autism-linked mutations may all point to common wiring defects. “If we could find that, we might have a handle to understand the condition and maybe do something about it genetically,” [researcher Justus] Kebschull says. “We’re starting to work on that in the lab now.”

Read full, original post: “Bar Codes” Could Trace Errant Brain Wiring in Autism and Schizophrenia

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Infographic: The evolutionary history of the COVID-19 coronavirus

Infographic: The evolutionary history of the COVID-19 coronavirus

Reuters analysed over 185,000 genome samples from the Global Initiative on Sharing All influenza Data (GISAID), the largest database of ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend