Can CRISPR gene editing save the Cavendish banana from extinction?

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When it comes to tropical fruits, Norwich [UK] probably isnโ€™t the first place that springs to mind. But here …. a team of banana experts led by a former Israeli naval commander is working feverishly to save the fruit from extinction.

โ€œBananas are the fourth most important food crop globally, itโ€™s the most consumed and produced food,โ€ says Gilad Gershon, chief executive of Tropic Biosciences.

…. For more than 20 years, tropical race 4 (TR4), a soil-borne strain of the Fusarium wilt fungus, has been slowly making its way across the world from south-east Asia, threatening to wreak havoc on the global banana industry.

Cavendish bananas are asexual, which means they canโ€™t be bred in a way that eliminates the genes putting them at risk, according to Gershon. So the company has put its gene-editing technology to work to mitigate challenges from the fungus.

Specifically, one of the main tools in the firmโ€™s arsenal of tools is CRISPR …. It’s technology works by taking a banana flower from a place like Colombia and reducing it to millions of stem cells in cultures. Then, sequences of the Cavendish banana genes that make it susceptible to TR4 fungus are cut out.

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