Stopping the ‘raging fire of Alzheimer’s’: Researchers shifting attention in fight against neurodegenerative diseases

alzheimers tau neuro
Tau tangles. Credit: Juan Gaertner/Shutterstock
This article or excerpt is included in the GLP’s daily curated selection of ideologically diverse news, opinion and analysis of biotechnology innovation.

Tau was long thought to be a secondary actor. Amyloid plaque builds up first, largely outside of neurons, followed by tau tangles—filaments of the tau protein—which clog their insides. But research has found that people can continue to function well with amyloid in their brain. It is only when toxic tau starts to spread that people begin confusing “breakfast” with “baseball,” forgetting not just where they left their keys but how to use them.

Now scientists in labs across the world are trying to better understand the role of tau in neurodegenerative diseases and to figure out ways to track and tame it before brain cells—and families—suffer.

Related article:  Treating OCD and other anxiety disorders with brief, intensive therapy

Researchers have only begun to understand what causes tau to turn toxic. A number of recent studies have suggested that the protein may take an aberrant turn after an inflammatory trigger, such as gum disease or an infection, or different conditions, such as “leaky gut.”

If this theory proves true, it suggests there might be ways to stop the spark of an infection or another untoward event from igniting the raging fire of Alzheimer’s. But it is still very early days, [researcher Michel] Goedert notes, and more work needs to be done.

Read the original post

Share via
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend