Stem cell transplants show promise as possible AIDS cure

c d a dfa b

[A study] demonstrated a successful stem cell transplantation from donors harboring an HIV-resistant gene. Blood taken from the patient revealed an absence of no active viral infection 30 months following cessation of antiviral therapy.

The case report published in The Lancet HIV Journal effectively demonstrated the second person documented to have been cured to HIV. Crucially, although no active viral species remained in the patient’s blood, there was evidence of integrated HIV-1 DNA in the tissue sample.

The primary success of this study is the demonstration of the complete absence of HIV-1 replication in samples of multiple bodily fluids including cerebrospinal, blood, intestinal, semen, and lymphoid tissue. The remnants of integrated HIV-1 are regarded as ‘fossils.

Although promising, the treatment is high-risk. This places this treatment as a viable offer for patients only suffering from hematological malignancies as a last resort.

Related article:  The tricky path for using stem cells to treat coronavirus-ravaged lungs

This study also represents the use of CCR5 gene editing as a curative therapy outside of gene editing. Although promising the scalability of CCR5 gene editing is limited – following technical and ethical barriers associated with its use.

Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

As the London patient is only the second case study at present, Gupta et al. caution that several barriers remain to be overcome. These include the robustness of safety data and the efficiency of gene editing techniques used in the process.

Read the original post

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
can you boost your immune system to prevent coronavirus spread x

Video: How to boost your immune system to guard against COVID and other illnesses

Scientists have recently developed ways to measure your immune age. Fortunately, it turns out your immune age can go down ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend