A brief history of the revolutionary impact of psychedelic therapy

Credit: Alex Dos Diaz/Verywell
Credit: Alex Dos Diaz/Verywell

In the last 10 years, psychedelic drugs like LSD, magic mushrooms, DMT, a host of “plant medicines” – including ayahuasca, iboga, salvia, peyote – and related compounds like MDMA and ketamine have begun to lose much of their 1960s-driven stigma. Promising clinical trials suggest that psychedelics may prove game-changing treatments for depression, PTSD and addiction. The response from the psychiatric community, far from dismissive or even sceptical, has been largely open-armed. The drugs may well mark the field’s first paradigm shift since SSRIs in the 1980s.

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This wave of psychedelic enthusiasm in psychiatry isn’t the first. They were originally heralded as wonder drugs in the 1950s.

Across some 6,000 studies on over 40,000 patients, psychedelics were tried as experimental treatments for an extraordinary range of conditions: alcoholism, depression, schizophrenia, criminal recidivism, childhood autism. Participants included artists, writers, creatives, engineers and scientists. And the results were promising. 

It wouldn’t last. By October 1966, LSD was banned in California, with federal restrictions to follow in 1970 under the Controlled Substances Act.

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