Scientists at the University of Cambridge have identified the genetic mutation responsible for progressive retinal atrophy (PRA) in English Shepherd Dogs. This discovery not only pinpoints the cause of this incurable blindness but also provides a genetic test to help eradicate the disease for good from future generations.
The team from Cambridge has developed a DNA test that can detect the mutation causing PRA. Breeders can now identify carriers of the disease before any symptoms appear. Consequently, informed breeding decisions can prevent the faulty gene from being passed to puppies.
Most dog owners are unaware their pet has PRA until the dog is middle-aged, often after it has already bred. This delay has made controlling the disease virtually impossible.
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The research team believes their work on PRA could offer insights into the human version of the disease and potentially identify targets for gene therapy.
This discovery marks the thirty-third genetic mutation causing an inherited disease in dogs identified by the team, with 23 of these affecting vision. The research underscores the impact of selective breeding on canine health and the potential benefits of genetic testing in preserving the well-being of dog breeds.
