Last year, this team reported recurrent changes in the genomes of human pluripotent stem cells as they are expanded in culture. The current report, which appears in the May 4, 2012 issue of the journal Cell Stem Cell, shows that these cells can also change their epigenomes, the patterns of DNA modifications that regulate the activity of specific genes—sometimes radically. These changes may influence the cells’ abilities to serve as models of human disease and development.
View the original article here: Study reveals dynamic changes in gene regulation in human stem cells – Phys.Org
