Two large-scale gene association projects have identified a large number of new loci that influence glycemic traits such as blood glucose and insulin levels, and impact on the risk of type 2 diabetes. The two research consortia report their data independently in Nature Genetics, and hope the results will provide new insights into the genetic networks and mechanisms that control glucose and insulin, and the genetic interplay that impacts on susceptibility to type 2 diabetes.
Meta-analyses of genome-wide association studies (GWAS) previously carried out by the Meta-Analysis of Glucose and Insulin-related traits Consortium (MAGIC) had identified multiple loci associated with glycemic traits including fasting glucose, fasting insulin, and post-challenge glucose concentrations. However, while this work had highlighted important biological pathways, the costs associated with de novo genotyping meant only a limited number of loci from discovery analyses were taken forward in to follow-up analyses.
View the original article here: New genetic risk factors for diabetes discovered