Stem cell transplants may show promise for MS

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New research suggests that stem cell transplants to treat certain brain and nervous system diseases such as multiple sclerosismay be moving closer to reality.

One study found that experimental stem cell transplants are safe and possibly effective in children with a rare genetic brain disease. Another study in mice showed that these cells are capable of transforming into, and functioning as, the healthy cell type. The stem cells used in the two studies were developed by study sponsor StemCells, Inc.

View the original article here: Stem Cell Transplants May Show Promise for MS – WebMD

In first, Indian stem cells sent abroad to treat London patient

In the first case of its kind in the country, stem cells from a 50-year-old woman in Nagpur were donated to treat a patient abroad — a 40-year-old South Asian suffering from blood cancer and awaiting a transplant in a London hospital.

The process of providing the donor cells was monitored by Chennai-based NGO Datri, which is working to create a global database of potential donors that can be accessed by any patient suffering from disorders such as leukaemia and lymphoma and need stem cell transplant.

View the original article here: In first, Indian stem cells sent abroad to treat London patient – Financial Express

Stem cells transplanted in human brain create myelin

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Neural stem cells transplanted into the brains of people with Pelizaeus-Merzbacher disease (PMD) can differentiate and begin producing the myelin sheaths that these patients lack, according to results of a Phase I clinical trial published today (October 10) in Science Translational Medicine. Myelin, the fatty insulating layer wrapped around nerve axons, is essential for proper nerve signaling. Researchers hope that these stem cell-derived myelin-producing cells may someday help patients recover brain function.

“This is an encouraging first step,” said neurogeneticist Grace Hobson at Nemours Biomedical Research in Delaware, who investigates PMD but did not participate in the research. The disease currently has no treatment, but the new results give hope that stem cell transplantation may one day help restore nerve function in PMD patients, she said.

View the original article here: Stem Cells Myelinate Human Brain – Scientist (blog)

An Indian smallholder farmer speaks out: “Allow us to embrace biotechnology”

My last visit to the United States changed the way I farm on the other side of the world.

In 2009, I traveled from India to Des Moines to attend the Global Farmers Roundtable, a project of Truth about Trade and Technology, held in conjunction with the World Food Prize. I met farmers from Iowa as well as Australia, Honduras, South Africa, and elsewhere. We learned about each other’s work, discussed common challenges and opportunities, and enjoyed some of the best sweet corn I’ve ever tasted.

When I returned to India, I worked with a group of local farmers to open a new sweet corn processing factory. The knowledge I gained in the United States made it possible. I’ll always be grateful to Iowa and the people I met at the Global Farmer Roundtable and World Food Prize for pointing us in the right direction.

View the original article here: An Indian Smallholder Farmer Speaks Out: Allow Us to Embrace Biotechnology

US panel urges end to secret DNA testing over privacy concerns

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They’re called discreet DNA samples, and the Elk Grove, California, genetic-testing company easyDNA says it can handle many kinds, from toothpicks to tampons.

Blood stains from bandages and tampons? Ship them in a paper envelope for paternity, ancestry or health testing. EasyDNA also welcomes cigarette butts (two to four), dental floss (“do not touch the floss with your fingers”), razor clippings, gum, toothpicks, licked stamps and used tissues if the more standard cheek swab or tube of saliva isn’t obtainable.

If the availability of such services seems like an invitation to mischief or worse – imagine a discarded tissue from a prospective employee being tested to determine whether she’s at risk for an expensive disease, for instance – the Presidential Commission for the Study of Bioethical Issues agrees.

View the original article here: US panel urges end to secret DNA testing over privacy concerns – Fox News

Scientists challenge organic backer Benbrook claims that GM crops increase pesticide spraying

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The ongoing hullabaloo over the controversial Seralini study and questions about the safety of foods made from genetic modified crops has obscured another line of attack on biotechnology by the Hydra of GM critics: claims that GM crops are environmentally unfriendly.

Noted organic scientist Charles Benbrook of the University of Washington recently released a summary of his published study assessing the use of pesticides since the introduction of GM crops in the 1990s. A fierce and respected critic of GM technology, Benbrook claims his data shows that pesticide use has gone up in the US over that time.

News coverage of the Benbrook study was motley and often highly politicized. There was the expected selective presentations from anti-GM journalists such as Tom Laskawy at Grist, Tom Philpott at Mother Jones and at organic publisher Rodale. But more disappointing was the botched context provided by more mainstream sources. Reuters, for example, echoed Benbrook’s views uncritically, blaring in a headline that “GMO crop technology backfires.”

Within days of the first wave of media coverage, the more responsible press weighed in and contextualized analysis emerged. Keith Kloor, the respected Slate contributing writer, offered his analysis of how many reporters misplayed the story out of the gate.

Former UC Davis scientist Steve Savage, who had nice things to say about Benbrook, put the organic advocates claims in a different perspective, and reached a far different conclusion. He viewed the extremely modest multi-year increase in the use of some pesticides—less toxic versions than ones used previously—as a sign of significant environmental progress.

The blog Big Picture Agriculture broke down Benbrook’s numbers and found that pesticide use is actually falling on a yield per acre basis—in accord with what biotech proponents have claimed would happen—but warned that trouble may lie ahead.

Environmental consensus emerging on relative safety of GM crops

Benbrook’s broadside aside, what’s most interesting as the debate unfolds are signs that a scientific consensus is gradually but surely emerging that GM crops do not pose unmanageable environmental threats. Supporters and critics of biotech crops agree that crops bred for a natural resistance to pests harm biodiversity less than conventional crops because glyphosate, the pesticide used in conjunction with GM crops, is less persistent in the environment and less toxic to animals.

As New Scientist noted this week conservationists, once diehard opponents, have sharply reduced their vitriolic opposition. It noted, for example, that in 2004, the International Union for Conservation of Nature called for a halt to the release of GM organisms, but by 2007 it had published a report saying there was “no conclusive evidence of direct negative impacts on biodiversity of GMOs that have been commercially released”.

By 2010, Michael Marshall also noted, the once skeptical US National Research Council Reporter had concluded: “[G]enerally, GM crops have had fewer adverse effects on the environment than non-GM crops produced conventionally”. The same year, a European Union report summarized 10 years of research, saying GM crops “are not per se more risky”.

The evolution in views, Marshall wrote, is largely because “claiming that GM crops are environmentally harmful is difficult to back up.” But what about Benbrook’s claims? The magazine quoted scientists who believe there are more than nits to pick with his methodology and conclusions.

Benbrook made subjective estimates of herbicide use because the data, provided by the US National Agricultural Statistics Service, doesn’t differentiate between GM and non-GM crops, said Graham Brookes of PG Economics, a consultancy firm in Dorchester, UK. Brookes crunched the almost identical data and published a peer reviewed report earlier this year that reached a far different conclusion: GM crops may actually have reduced worldwide pesticide use by 9.1 per cent.

The disparity can also be explained by the unique toxic profile of glyphosate. While traditional herbicides don’t work on all weeds, resulting in farmers spraying their fields multiple times, the far more effective glyphosate, which attacks most weeds, can be sprayed fewer times for the same effect.

Every technology comes with trade offs. Farmers have seen an emergence of weed varieties—22 at current count—that are resistant to glyphosate. That’s a problem in conventional agriculture as well of course. So-called superweeds may signal danger ahead—or as New Scientist suggests, perhaps it’s only a temporary reflection of the current market reality that farmers have a limited menu of GM crops to choose from. With more variety of crops using different pesticides, resistant-specific weeds would be less likely to emerge. The issue then morphs into a debate over patent protections and not the science behind GM technology.

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Race and intelligence

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There is no more explosive issue in human genetics than the issue of race and IQ. Ron Unz, a leading thinker in what’s called the ‘human biodiversity’ movement, framed the ongoing debate in a July cover story in the American Conservative. It stimulated dozens of responses and counter-responses, discussing everything from the dangers of racial categorization to the role of the “Flynn Effect” in interpreting IQ data.

View the original article here: Race and intelligence

Lawyer: Prop 37 will overtake Prop 65 as a source of consumer litigation in California

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Prop 37 is likely to surpass Prop 65 as a source of consumer litigation in California if the controversial GMO labeling initiative gets the green light next month, predicts one San Francisco-based lawyer.

View the original article here: Lawyer: Prop 37 will overtake Prop 65 as a source of consumer litigation in … – FoodNavigator-USA.com

Prop 37 voter guide has confused voters and misrepresented our position, says Academy of Nutrition and Dietetics

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The official voter information guide on California’s Proposition 37 GMO labeling initiative inaccurately states that the Academy of Nutrition and Dietetics “has concluded that biotech foods are safe”. However, this position has expired, and the Academy of Nutrition and Dietetics currently does not have a position on GM foods.

View the original article here: Prop 37 voter guide has confused voters and misrepresented our position, says … – FoodNavigator-USA.com

Genoeconomics: Is our financial future in our chromosomes?

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The GLP carried a provocative article this week outlining the latest twist in the emerging debate over genoeconomics—the nexus of genetics and economics. The prestigious American Economic Review is set to publish a peer reviewed paper co-authored by two economists, Quamrul Ashraf and Oded Galor, that argues that a country’s economic well being could be linked to the population’s genetic make-up. Earlier versions of the article have been available on the web for a few years, and it’s stirred quite a controversy.

According to a summary of the paper in Nature: “The paper argues that there are strong links between estimates of genetic diversity for 145 countries and per-capita incomes, even after accounting for myriad factors such as economic-based migration. High genetic diversity in a country’s population is linked with greater innovation, the paper says, because diverse populations have a greater range of cognitive abilities and styles. By contrast, low genetic diversity tends to produce societies with greater interpersonal trust, because there are fewer differences between populations. Countries with intermediate levels of diversity, such as the United States, balance these factors and have the most productive economies as a result, the economists conclude.”

The term “genoeconomics” was coined only a few years ago. Spurred by groundbreaking public policy and social and economic research at the University of Chicago over the past two decades, economists have been expanding their wings, exploring the role of economic factors culture. The subject became mainstream after the bestselling success in 2005 of Freakonomics: A Rogue Economist Explores the Hidden Side of Everything by UC economist Steven Levitt and New York Times journalist Stephen Dubner. Within a few years, economists began turning their sites on the intersection of genetics and economics.

In May, the Boston Globe ran a fascinating piece, In Search of the Money Gene, featuring some of the young pioneers, Phillip Koellinger, now a professor at Erasmus college, then a MIT student but now a professor at New York University. Within a few years, a plethora of the best and the brightest in economics had jumped into the field—and the fray.

Their basic premise—which is incontestable in its most superficial form—is that genetics underlies many of the things, like risk-taking, patience and generosity that society has traditionally assumed are shaped totally by social and environmental factors. The challenge is to what degree scientists can tease out these genetic factors and what patterns might be found in various genetic groups, such as by sex or countries or ethnic and religious populations. Clearly, it’s potentially explosive stuff.

Leon Neyfakh in the Globe traces the movement—that’s what it has already become—to 1976, when the late University of Pennsylvania economist Paul Taubman published the results of a study in which he followed the financial lives of identical twins. The congruence in their “economic lives”—even in cases in which identical twins had been separated and raised in different cultural situations—was striking. Taubman estimated that between 18 percent and 41 percent of variation in income across individuals was heritable. Spurred by the completion of the Human Genome Project in 2000 and the budding of the field of neuroeconomics (the study of how economic decision-making functioned inside a person’s brain), the groundwork was laid for the emergence of genoeconomics.

It’s fascinating and controversial research. “I’m really worried that if [tracing behaviors to genes] should become possible, it may lead to a lot of things that we don’t want,” Neyfakh quotes Koellinger as saying. “I very firmly believe that information about your genetic makeup is probably the most private thing you could possibly have, and there should be extremely tight protections to make sure that no one gets their hands on this data unless you as an individual explicitly want this.”

No wonder that Ashraf and Galor’s paper is already prompting out-cries from the “we shouldn’t be discussing such things” crowd. The digital ink is not even dry and yet the authors are facing charges of genetic determinism and racism. Geneticist David Reich of Harvard Medical School in Boston, Harvard University paleoanthropologist Daniel Lieberman and more than a dozen other Harard professors have written an open letter highly critical of the paper and decrying its potential for mischief: “[T]he suggestion that an ideal level of genetic variation could foster economic growth and could even be engineered has the potential to be misused with frightening consequences to justify indefensible practices such as ethnic cleansing or genocide,” the letter said.

The reaction comes across as overheated. The paper had in fact been peer reviewed by economists and biologists and is not presented as definitive. Ashraf and Oder make a point of noting that they are merely using genetics as a proxy for other factors that can drive an economy, such as history and culture, so charges of determinism appear misplaced, serving mostly to raise the threat of soft censorship.

A taboo invariably emerges when the nexus of genetics and social patterns are discussed—issues engaged comprehensively by GLP executive director Jon Entine in two of his books, Taboo: Why Black Athletes Dominate Sports and Why We’re Afraid to Talk About It and Abraham’s Children: Race, Identity and the DNA of the Chosen People.

This is not an endorsement of this latest article in the ‘gene wars’ debate. It is a reminder that genetics is opening wide new doors of inquiry. It would be dangerous to close them because inquiries into human differences have been misused in a pre-genetic era. As we never know where new advances in science will originate we’re far better served by vigorous debate. Let’s hope more researchers pursue this subject and with even more intellectual rigor—and their work is welcomed as a appropriate subject for debate and discussion.

Scientists believe DNA has half life of more than 500 years

Few researchers have given credence to claims that samples of dinosaur DNA have survived to the present day, but no one knew just how long it would take for genetic material to fall apart. Now, a study of fossils found in New Zealand is laying the matter to rest — and putting paid to hopes of cloning a Tyrannosaurus rex.

After cell death, enzymes start to break down the bonds between the nucleotides that form the backbone of DNA, and micro-organisms speed the decay. In the long run, however, reactions with water are thought to be responsible for most bond degradation. Groundwater is almost ubiquitous, so DNA in buried bone samples should, in theory, degrade at a set rate.

View the original article here: Scientists believe DNA has half life of more than 500 years

Anti-GMO activists urge labeling GM foods in Ontario

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As more and more evidence continues to come forward which suggests that genetically modified organisms may have adverse health effects on humans, people all over the world are becoming aware of this and are launching initiatives to force Monsanto to label their GMO’s. Today on Press For Truth TV we’re speaking with Zachary Schieck who has launched a campaign to have all GMO’s labeled in every grocery store in Ontario.

View the original article here: The Campaign To Label GMO’s In Ontario | Press For Truth

Billion dollar babies of the human genome

The Human Genome Project (HGP) deciphered the entirety of the human genetic code in just over a decade. Though science and medicine will take some time to sift through all of this information and make hay of it, the project, which cost US taxpayers nearly 4 billion dollars, has already had a tangible impact on the US economy by jumpstarting the booming genomics industry

 

Along with all of the supporting suppliers and technology companies, the industry has spawned hundreds of thousands of jobs and helped drive a total economic impact of nearly $800 billion, according to a study released yesterday (May 10) by Battelle, an independent science and technology research and development organization. “I can’t imagine a scientific undertaking sponsored by the federal government that has had this kind of fundamental impact and drive on the US economy,” said Simon Tripp of linkurl:Battelle,;http://www.battelle.org/ the report’s primary author. While it is impossible to attribute the entirety of the genomics and genomics-enabled industries to the HGP, he added, the overwhelming consensus among those in the field is that it was fundamental to their growth. “If you talk to people in the industry, they all say the HGP was foundational in building the genomics industry. You wouldn’t be able say that the entire internet is because of DARPA’s original expenditures in the ARPANET, but it was certainly foundational in its creation.”

View the original article here: Billion dollar babies of the human genome – The Scientist Magazine®

Uphill fight waged to turn back Prop 37, says pro-GM supporter

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Vote no on California’s Prop 37. Most of you will. However, we are likely to be on the losing end of the vote. Polls are now showing the so called right-to-know food labeling proposition will pass by a 2 to 1 margin. (The people leading the fight against Prop 37 point out that this poll came out before they started their media campaign.)

The poll showed overwhelming support for Prop 37, despite the fact that it is a convoluted ballot initiative that defies definition. It is called an organic food referendum; an anti-science/anti-biotechnology statement; a food fight; anti-Monsanto; a food safety initiative; and a pushback against junk food among other definitions.

View the original article here: Uphill fight waged to turn back Prop 37 – Western Farm Press (blog)

DNA’s half-life identified using fossil bones

We are used to radioactive substances having a half-life, but DNA? Now a study of bones from extinct birds suggests the double helix too has a measurable half-life – and that we have underestimated its ability to survive in the fossil record.

“DNA degrades at a certain rate, and it therefore makes sense to talk about a half-life,” says Morten Allentoft at Copenhagen University, Denmark, who together with Mike Bunce at Murdoch University in Perth, Australia, and colleagues, extracted DNA from the leg bones of 158 extinct flightless birds called moas.

View the original article here: DNA’s half-life identified using fossil bones

Was Lamarck right? How epigenetics may work

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While no biologist believes that organisms can willfully change their physiology in response to their environment and pass those changes on to their offspring, some evidence suggests that the environment can make lasting changes to the genome via epigenetic mechanisms—changes that may be passed on to future generations.

View the original article here: Was Lamarck right? How epigenetics may work

Scientists increasingly support sustainability advantages of GM crops

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The idea that genetic modification is in itself harmful now appears to be a minority viewpoint. Scientists are decisively coming around to the conviction that  there is little solid evidence that genetically modified crops are harmful to the environment, and many transgenic crops may even boast solid green credentials.
View the original article here: Scientists increasingly support sustainability advantages of GM crops

Genoeconomics: To uproar, researches say genetic diversity can predict economic success

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A yet-to-be-published article in an upcoming issue of the prestigious American Economic Review by two economics professors, peer reviewed by economists and biologists, argues that a country’s poverty could be the result of its citizens’ genetic make-up. It has already sparked charges of genetic determinism and racism–in some cases from critics who had not read the article–and has led to troubling calls to censor discussion of such issues on the grounds that such data “has the potential to be misused with frightening consequences to justify indefensible practices such as ethnic cleansing or genocide.”
 
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