Antidepressants kick in faster with the help of small interfering RNA

In a recent experiment, researchers tested if something called a small interfering RNA, which can restrict the effects of RNA interference to a small area, could help antidepressants work faster.

The authors looked at anxiety tests and antidepressant tests in mice. While the small interfering RNA had no effect on anxiety tests, in antidepressant tests (including the forced swim and tail suspension), the small interfering RNA made a big difference. And fast.

Obviously this is a long way from the clinic, but it’s an interesting angle, a direct attack on the 5-HT1A receptor to get the current antidepressants to work. And when looking for a good antidepressants, we will take whatever we can get.

Read the full, original story here: Knocking 5-HT1A down to bring mood up

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