Scientists studying the evolution of HIV in North America have found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design, researchers said. ‘Much research has focused on how HIV adapts to antiviral drugs — we wanted to investigate how HIV adapts to us, its human hosts, over time,’ said lead author Zabrina Brumme, an assistant professor in the Faculty of Health Sciences at Simon Fraser University.
‘HIV adapts to the immune response in reproducible ways. In theory, this could be bad news for host immunity — and vaccines — if such mutations were to spread in the population,’ said Brumme. ‘Just like transmitted drug resistance can compromise treatment success, transmitted immune escape mutations could erode our ability to naturally fight HIV,’ said Brumme. Researchers characterised the human immunodeficiency virus (HIV) sequences from patients dating from 1979, the beginning of the North American HIV epidemic, to the modern day
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