Woman’s rapid weight gain raises questions over fecal transplant

The case of a normal-weight woman who rapidly became obese after receiving a fecal transplant from an overweight relative has raised new concern over the screening of donated stool.

The patient, who underwent the novel procedure to treat a recurring bacterial infection in her intestines, has gained more than 40 pounds since the transplant and continues to gain weight, according to a case report published Wednesday in the journal Open Forum Infectious Diseases.

The patient has been unable to shed the unwanted weight through diet or exercise, according to her doctors.

“This case serves as a note of caution when considering the use of non-ideal donors for fecal microbiota transplant (FMT), and we recommend selecting non-overweight donors,” wrote the paper’s authors, Dr. Neha Alang, an internist at Rhode Island’s Newport Hospital; and Dr. Colleen Kelly, a gastroenterologist at the Warren Alpert Medical School of Brown University.

ADVERTISEMENT

It remains unclear exactly what caused the dramatic weight gain. However, the physicians note that studies conducted on mice show that lean mice can become fatter if they receive fecal microbes from overweight mice.

“We’re questioning whether there was something in the fecal transplant, where some of those ‘good’ bacteria we transferred may have had an impact on her metabolism in a negative way,” Kelly said in a prepared statement.

Viewed for many years as a fringe medical treatment with a high “snicker factor,” fecal transplants have recently shown promise in fighting Clostridium difficile infections.

Read full, original article: Did fecal transplant make woman obese?

ADVERTISEMENT
ADVERTISEMENT
Outbreak Daily Digest
Biotech Facts & Fallacies
GLP Podcasts
Infographic: Here’s where GM crops are grown around the world today

Infographic: Here’s where GM crops are grown around the world today

Do you know where biotech crops are grown in the world? This updated ISAAA infographics show where biotech crops were ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

* indicates required
Email Lists
Send this to a friend