Mini ‘placenta-on-a-chip’ gives closer look at mysterious organ

Researchers at the National Institutes of Health have created a “placenta-on-a-chip,” a miniature device that uses actual human cells to imitate the way a placenta works inside a pregnant woman’s body. They wrote about their findings in a paper published by The Journal of Maternal-Fetal & Neonatal Medicine.

“The device consists of a semi-permeable membrane between two tiny chambers, one filled with maternal cells derived from a delivered placenta and the other filled with fetal cells derived from an umbilical cord,” the NIH explained in a statement.

To test the model, researchers added glucose to the chamber of the device that contained maternal cells—then watched as the glucose was transferred through the semi-permeable membrane and over to the chamber of fetal cells, a process that that mirrors what happens when nutrients are passed through the placenta to a growing fetus.

“The chip may allow us to do experiments more efficiently and at a lower cost than animal studies,” said Roberto Romero, the chief of the perinatology research at the National Institute of Child Health and Human Development, in a statement. “We hope this technology may lead to better understanding of normal placental processes and placental disorders.”

Which brings us to some of the many weird things about placentas. Like how the placenta is the only organ found in humans that’s temporary, in the sense that it is routinely created and discarded. And how it has its own unique microbiome, trillions of microorganisms that are believed to influence how a newborn’s immune system works.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis. Read full, original post: A Human Placenta, the Size of a Computer Chip

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