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Driven by the quest for eternal youth, humankind has spent centuries obsessed with the question of how it is exactly that we age. With advancements in molecular genetic methods in recent decades, the search for the genes involved in the ageing process has greatly accelerated.
Researchers at ETH Zurich and the JenAge consortium from Jena have now systematically gone through the genomes of three different organisms in search of the genes associated with the ageing process that are present in all three species – and thus derived from the genes of a common ancestor. Although they are found in different organisms, these so-called orthologous genes are closely related to each other, and they are all found in humans, too.
In order to detect these genes, the researchers examined around 40,000 genes in the nematode C. elegans, zebra fish and mice. By screening them, the scientists wanted to determine which genes are regulated in an identical manner in all three organisms in each comparable ageing stage – young, mature and old; i.e. either are they upregulated or downregulated during ageing.
Out of this volume of information, the researchers used statistical models to establish an intersection of genes that were regulated in the same manner in the worms, fish and mice. This showed that the three organisms have only 30 genes in common that significantly influence the ageing process.
Read full, original post: Fountain of Youth: Tweaking Genes to Extend Lifespan