Oral cancer vaccine, with an assist from CRISPR, shows promise in treatment

ORALCANCER f

Certain cancers seem to have a predilection for Asians…[A]ccording to the World Health Organization (WHO), oral cancer is responsible for 11% of cancer deaths in Asia, compared to 4% in the rest of the world.

In immunotherapy, Prof Cheong Sok Ching, who heads the Oral Cancer Research Group at Cancer Research Malaysia (CRM), shares that her team has developed a potential vaccine for oral cancer, which is now poised to enter safety evaluation before starting clinical trials in humans.

The project plan…is to use the Crispr-Cas9 technology on the collection of head and neck cancer cells Prof Cheong has collected over the last decade from Malaysian patients – a collection [researchers] describe as “very unique and no one else on the planet has”.

[Prof. Cheong] adds that the collection is also special because betel-nut chewing is a risk factor that is unique to South-East Asia, compared to similar cancer cell lines in the West, which are usually associated with the risk factors of excessive alcohol consumption and smoking.

“The carcinogens could have an effect on what kind of mutations occur within the cancer,” she explains.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post: Using Crispr-Cas9 to find vulnerable oral cancer genes for a potential cure

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