CAR-T engineering of patients’ own T cells for cancer therapy gains traction

hivvirusandantibody e

The strategy of engineering patients’ own T cells for cancer therapy got two major endorsements in late August, one financial and one regulatory. First, Gilead Sciences of Foster City, California, announced plans on August 28 to dole out $11.9 billion to acquire Santa Monica, California–based Kite Pharma, one of the leading developers of chimeric antigen receptor (CAR)-T cell immunotherapies. Then, two days later, the US Food and Drug Administration (FDA) granted approval to the country’s first CAR-T cell product.

“It really marks a huge milestone for the field—and for cancer therapy as a whole—that relatively large commercial players now are in this space and are interested in providing a new kind of therapy for patients,” says Marcela Maus, a CAR-T researcher at the Massachusetts General Hospital in Boston.

There are also many challenges in manufacturing scale-up to overcome, notes Bruce Levine, founding director of the University of Pennsylvania’s Clinical Cell and Vaccine Production Facility, part of the Novartis–Penn Center for Advanced Cellular Therapeutics opened last year. “The field is in the spotlight,” he says. “And to be able to have something that is sustainable and can be available to more patients—not only in hematologic malignancies, but also solid cancers—we’ve got to make progress in manufacturing sciences, analytics, logistics and infrastructure.”

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post: Epic $12 billion deal and FDA’s approval raise CAR-T to new heights (behind paywall)

Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
can you boost your immune system to prevent coronavirus spread x

Video: How to boost your immune system to guard against COVID and other illnesses

Scientists have recently developed ways to measure your immune age. Fortunately, it turns out your immune age can go down ...
mag insects image superjumbo v

Disaster interrupted: Which farming system better preserves insect populations: Organic or conventional?

A three-year run of fragmentary Armageddon-like studies had primed the journalism pumps and settled the media framing about the future ...
dead bee desolate city

Are we facing an ‘Insect Apocalypse’ caused by ‘intensive, industrial’ farming and agricultural chemicals? The media say yes; Science says ‘no’

The media call it the “Insect Apocalypse”. In the past three years, the phrase has become an accepted truth of ...
globalmethanebudget globalcarbonproject cropped x

Infographic: Cows cause climate change? Agriculture scientist says ‘belching bovines’ get too much blame

A recent interview by Caroline Stocks, a UK journalist who writes about food, agriculture and the environment, of air quality ...
organic hillside sweet corn x

Organic v conventional using GMOs: Which is the more sustainable farming?

Many consumers spend more for organic food to avoid genetically modified products in part because they believe that “industrial agriculture” ...
benjamin franklin x

Are most GMO safety studies funded by industry?

The assertion that biotech companies do the research and the government just signs off on it is false ...
gmo corn field x

Do GMO Bt (insect-resistant) crops pose a threat to human health or the environment?

Bt is a bacterium found organically in the soil. It is extremely effective in repelling or killing target insects but ...

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies for tighter GMO legislation and famously puts out annual "dirty dozen" list of fruits and ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be the prime mover behind the ongoing campaign against agricultural biotechnology at Consumer Reports. He is an ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
Optional. Mail on special occasions.
Send this to a friend