There are literally no more studies we can do to show glyphosate is safe, expert says

| | October 19, 2018

Several days ago I wrote a column about the wrong-headed claim that glyphosate is a carcinogen and the huge number of tort cases that has resulted from this error. It was only after I posted the column that a naïve question presented itself, Why is there so little government research on the toxicity of glyphosate, particularly from the FDA, which is responsible for food safety? After all, the FDA has studied a wide range of contaminants that occur in food and animal feed, including soy phytoestrogens, arsenic, acrylamide, pigments, and combustion products.

I put this question to a veteran scientist who has spent his/her career studying the toxicity of various compounds for the federal government …. [Glyphosate] has been in use for over forty years and …. has been so thoroughly studied for toxicity and the concentrations found in humans are so low that there is no need for further study …. there is really nothing left to justify further research!

Related article:  Genetic Literacy Project’s Top 6 Stories for the Week

In conclusion, my contact made a stunning comment which puts the vexed issue of glyphosate — and other similar controversies — in a very different perspective,

“There is nothing left to understand, except how groups of humans can be incited to question the underlying science.  Oh, right, IARC and Prop 65.” 

Read full, original article: Tribal Epistemology: The Final Frontier

The GLP aggregated and excerpted this article to reflect the diversity of news, opinion, and analysis. Click the link above to read the full, original article.

50 thoughts on “There are literally no more studies we can do to show glyphosate is safe, expert says”

    • Unfortunately for your argument, I have absolutely no connection with Monsanto or any other vested interest in this controversy. I have done research on the causes and prevention of cancer for the past 40 and have been funded by the federal government (National Cancer Institute) and by the Albert Einstein College of Medicine. I’ve written over 150 scientific articles on factors that may play a role as risk factors or protective factors. https://www.ncbi.nlm.nih.gov/pubmed/?term=kabat+g
      Maybe you ought to take a look at your our beliefs.

      • Again, spoken like a true paid scientist. So when you worked for the national cancer institute, you weren’t paid? Look, cancer is good business and business is good. Who do you think funds the institute?

        • You just reveal how little you know. NIH is funded by taxes. I didn’t “work for” the Natl Cancer Institute. I worked for universities and was funded by competitive grants from NIH. You just have no interest in informing yourself about the basic facts of how things work.

          • You are funny. So all grant money comes from taxes? You just prey on people’s ignorance. Money buys the outcome of science based in who’s money it is. The only fact you most need to know. Thanks for playing.

          • I have been using glyphosate my entire career and I for one don’t want to eat ANYTHING sprayed with. Go eat up Mr. Cancer pays my salary scientist.

          • Wow, you think it’s dangerous and would never use it, but you do put it on other people’s food for money. Project your own guilty feelings on others much?

          • Is that your opinion? My “opinion” is bases on one fact. Round up is poison. Is that a fact or opinion?

          • Everything is poison at the right dose and not poison at a lower dose. At the minute doses humans are exposed to it is not a poison.

            Possibly a course in toxicology would help you? Or are all the professors & textbooks in on the big conspiracy?

        • Yes, a true paid scientist that does science.

          You would rather use guess work and jump to conclusions which has been responsible for solving zero safety and health concerns.

        • If you want to bolster your argument, please disclose your name, post a copy of your 2017 tax return, and a list of sources of income and any potential conflicts of interest.
          Otherwise, STFU.

          Your Disqus posts correlate 100% with this single article. Have you thought about branching out other topics, or is this your sole area of expertise?

    • The subtext of this makes so little sense. Imagine the same thing being said of a plumber’s opinion on your houses plumbing… “spoken like a true paidor plumber” – I would think that I should take the advice given by the plumber, after all plumbing is what he spends his working day on, so his opinion on plumbing should carry more weight than an unpaid armchair plumber, and more still than that of someone who doesn’t plumb at all.

  1. Another fraudulent claim or missing information regarding the real and present danger of Roundup Ready.

    Glyphosate is the only ingredient listed as active which in itself is another fraudulent claim by Monsanto. There is plenty of science that is reputable and honest but as usual industry always has a well-oiled machine to subvert and Destroy evidence by lies and manipulation, propaganda and the usual wickedness.

    Fake news… Apparently supplies a very handsome living to those that indulge in it.

      • Ingredients in RoundUp

        RoundUp herbicide by Monsanto contains the following ingredients:

        In a letter forwarded to Northwest Coalition for Alternatives to Pesticides, Monsanto identified RoundUp’s ingredients as:

        Isopropylamine salt of glyphosate (active ingredient)
        Water
        The ethoxylated tallowamine surfactant
        Related organic acids of glyphosate
        Excess isopropylamine

        According to the US Environmental Protection Agency in a letter dated April 30, 1999, in response to a Freedom of Information Request, the following inert ingredients are in RoundUp Super Concentrate Weed & Grass Killer:
        Polyoxyethylene alkylamine (CAS #61791-2)
        Water (CAS #7732-18-5)
        FD&C Blue No. 1 (CAS #3844-45-9)

        David H. Monroe, an Industrial and Environmental Toxicologist, stated in an October 16, 1989 letter to the National Campaign Against the Misuse of Pesticides (NCAMP) that most polyalkoxylated surfactants such as the polyoxyethylene alkylamine in RoundUp are contaminated with 1,4-dioxane. A study done by Monroe on Vision, a glyphosate product by Monsanto, revealed that it contained 1,4-dioxane at a level of 350 ppm.

        (Monroe D, 1989. Letter to NCAMP.)

        1,4-dioxane is carcinogenic, and is known to damage the liver, kidney, brain and lungs.

          • No, dear. All of the ingredients used in a herbicide must be tested and approved. Your information is in accurate.

          • It is amazing how “approval” or “allowed no longer means safe. It lust means allowed, but sadly at great expense to the public. Tobacco industry is the exquisite example, amongst thousands of others where products are allowed for profit while creating disease.

            A new study from Poland has shown how the herbicide Roundup 360 Plus causes DNA damage in human peripheral blood mononuclear cells (PBMCs) at low concentrations and how glyphosate and AMPA cause DNA damage in the same cells at higher concentrations.

            The mechanism of DNA damage induced by Roundup 360 PLUS,
            glyphosate and AMPA in human peripheral blood mononuclear cells –
            genotoxic risk assessement Full Paper: https://www.sciencedirect.com/science/artic/pii/S0278691518304800

            Authors: Ewelina Woźniak, Paulina Sicińska, Jaromir
            Michałowicz, Katarzyna Woźniak, Edyta Reszka, Bogumiła Huras, Jerzy
            Zakrzewski, Bożena Bukowska

            Abstract:

            Glyphosate is the most heavily applied among pesticides in the world, and thus human exposure to this substance continues to increase. WHO changed classification of glyphosate to probably cancerogenic to humans, thus there is urgent need to assess in detail genotoxic mechanism of its action. We have assessed the effect of glyphosate, its formulation (Roundup 360 PLUS) and its main metabolite
            (aminomethylphosphonic acid, AMPA) in the concentration range from 1 to 1000 μM on DNA damage in human peripheral blood mononuclear cells (PBMCs) incubated. The cells were incubated for 24 h. The compounds studied and formulation induced DNA single and double strand-breaks and caused purines and pyrimidines oxidation. None of compounds examined was capable of creating adducts with DNA, while those substances increased ROS (including •OH) level in PBMCs. Roundup 360 PLUS caused damage to
            DNA even at 5 μM, while glyphosate and particularly AMPA induced DNA particularly AMPA induced DNA lesions from the concentration of 250 μM and 500 μM, respectively. DNA damage induced by glyphosate and its derivatives increased in order: AMPA, glyphosate, Roundup 360 PLUS. We may conclude that observed changes were not associated with direct interaction of xenobiotics studied with DNA, but the most probably they occurred through ROS–mediated effects.

            Glyphosate Herbicides Linked to Uterine Hyperplasia at Low Concentrations

            A new study from Argentina, has shown that early postnatal exposure
            to low doses of a glyphosate-based herbicide enhances the sensitivity ofthe rat uterus to estradiol, and induces histomorphological and molecular changes associated with uterine hyperplasia.

            Glyphosate-based herbicide enhances the uterine sensitivity to estradiol in rats

            Final Study: http://www.ncbi.nlm.nih.gov

            Authors: Guerrero Schimpf M, Milesi MM, Luque EH, Varayoud J.

            Abstract

            In a previous work, we detected that postnatal exposure to a
            glyphosate-based herbicide (GBH) alters uterine development in
            prepubertal rats causing endometrial hyperplasia and increasing cell
            proliferation. Our goal was to determine whether exposure to low-dose of a GBH during postnatal development might enhance the sensitivity of the uterus to an estrogenic treatment. Female Wistar pups were subcutaneously injected with saline solution (control) or GBH using the reference dose (2 mg/kg/day, EPA) on postnatal days (PND) 1, 3, 5, and 7. At weaning (PND21), female rats were bilaterally ovariectomized and treated with silastic capsules containing 17β-estradiol (E2, 1mg/ml) until they were two months of age. On PND60, uterine samples were removed and processed for histology, immunohistochemistry and mRNA extraction to evaluate: i) uterine morphology, ii) uterine cell proliferation by the detection of Ki67, iii) the expression of the estrogen receptors alpha (ESR1) and beta (ESR2), and iv) the expression of WNT7A and β-catenin. GBH-exposed animals showed increased luminal epithelial height and stromal nuclei density. The luminal and glandular epithelium were markedly hyperplastic in 43% of GBH-exposed animals. GBH
            exposure caused an increase in E2-induced cell proliferation in
            association with an induction of both ESR1 and ESR2. GBH treatment decreased membranous and cytoplasmic expression of β-catenin in luminal and glandular epithelial cells and increased WNT7A expression in the luminal epithelium. These results suggest that early postnatal exposure to a GBH enhances the sensitivity of the rat uterus to estradiol, and induces histomorphological and molecular changes associated with uterine hyperplasia.

        • So… because none of the actual ingredients in roundup are known to be carcinogeninc, you make assumptions about ingredients that aren’t actually included in any of the formulations of roundup on the market?

          Yah… that seems reasonable.

        • Dr. Wozniak: Roundup Damages DNA in Human Blood Cells at Low Concentrations

          A new study from Poland has shown how the herbicide Roundup 360 Plus causes DNA damage in human peripheral blood mononuclear cells
          (PBMCs) at low concentrations and how glyphosate and AMPA cause DNA damage in the same cells at higher concentrations.

          The mechanism of DNA damage induced by Roundup 360 PLUS, glyphosate and AMPA in human peripheral blood mononuclear cells –genotoxic risk assessement

          Full Paper: https://www.sciencedirect.com/science/article/pii/S0278691518304800

          Authors: Ewelina Woźniak, Paulina Sicińska, Jaromir
          Michałowicz, Katarzyna Woźniak, Edyta Reszka, Bogumiła Huras, Jerzy
          Zakrzewski, Bożena Bukowska

          Abstract:

          Glyphosate is the most heavily applied among pesticides in the world, and thus human exposure to this substance continues to increase. WHO changed classification of glyphosate to probably cancerogenic to humans, thus there is urgent need to assess in detail genotoxic mechanism of its action. We have assessed the effect of glyphosate, its formulation (Roundup 360 PLUS) and its main metabolite (aminomethylphosphonic acid, AMPA) in the concentration range from 1 to 1000 μM on DNA damage in human peripheral blood mononuclear cells (PBMCs) incubated. The cells were incubated for 24 h. The compounds studied and formulation induced DNA single and double strand-breaks and caused purines and pyrimidines oxidation. None of compounds examined was capable of creating adducts with DNA, while those substances increased ROS (including •OH) level in PBMCs. Roundup 360 PLUS caused damage to DNA even at 5 μM, while glyphosate and particularly AMPA induced DNA lesions from the concentration of 250 μM and 500 μM, respectively. DNA damage induced by glyphosate and its derivatives increased in order: AMPA, glyphosate, Roundup 360 PLUS. We may conclude that observed changes were not associated with direct interaction of xenobiotics studied with DNA, but the most probably they occurred through ROS–mediated effects.

          • In vitro. Blood cells are fragile critters. When you soak them in 500 ppm of an herbicide with a surfactant (the ‘soap-like’ compound used to help the active ingredient penetrate plant cells) they generate DNA damage from reactive oxygen. At residual levels found (< 1 ppm) your blood cells will never experience these concentrations. Once again, good work that has been extrapolated where it cannot be meaningfully extrapolated.

          • Hi Rene, I don’t have access to the full paper. What were the specific culture conditions used where damage was seen?

          • Well played. LOL, like he actually read the paper, rather than skimming and copypasting a blogpost verbatim.

          • Peter here is the manuscript https://bit.ly/2AnnwQV My personal experience with comet assay is , that it is not very sensitive. We have used it to measure genotoxic and mutagenic effects of different chemicals on plants and plants celles, and it showed in comets only after the plants looked quite crippled. Comet assays on mammalian cells might be more sensitive though.

          • Next time they do this trick, they should try it with three petri dishes containing human cell samples. In the first one they can add a drop of Roundup. In the second one, a drop of fresh organic tomato juice. And in the third one they can squeeze the contents of one of Dr. Mercola’s Krill Oil capsules with evening primrose oil (for women).

            It shouldn’t surprise anyone to find the same outcome for all three cell treatment groups. It’s a cheap parlour trick intended to obfuscate and mislead.

        • Glyphosate Herbicides Linked to Uterine Hyperplasia at Low Concentrations

          A new study from Argentina, has shown that early postnatal exposure to low doses of a glyphosate-based herbicide enhances the sensitivity ofthe rat uterus to estradiol, and induces histomorphological and molecular changes associated with uterine hyperplasia.

          Glyphosate-based herbicide enhances the uterine sensitivity to estradiol in rats

          Final Study: http://www.ncbi.nlm.nih.gov

          Authors: Guerrero Schimpf M, Milesi MM, Luque EH, Varayoud J.

          Abstract

          In a previous work, we detected that postnatal exposure to a glyphosate-based herbicide (GBH) alters uterine development in prepubertal rats causing endometrial hyperplasia and increasing cell proliferation. Our goal was to determine whether exposure to low-dose of a GBH during postnatal development might enhance the sensitivity of the uterus to an estrogenic treatment. Female Wistar pups were subcutaneouslyinjected with saline solution (control) or GBH using the reference dose (2 mg/kg/day, EPA) on postnatal days (PND) 1, 3, 5, and 7. At weaning (PND21), female rats were bilaterally ovariectomized and treated with silastic capsules containing 17β-estradiol (E2, 1mg/ml) until they were two months of age. On PND60, uterine samples were removed and processed for histology, immunohistochemistry and mRNA extraction to evaluate: i) uterine morphology, ii) uterine cell proliferation by the detection of Ki67, iii) the expression of the estrogen receptors alpha (ESR1) and beta (ESR2), and iv) the expression of WNT7A and β-catenin. GBH-exposed animals showed increased luminal epithelial height and stromal nuclei density. The luminal and glandular
          epithelium were markedly hyperplastic in 43% of GBH-exposed animals. GBH exposure caused an increase in E2-induced cell proliferation in
          association with an induction of both ESR1 and ESR2. GBH treatment decreased membranous and cytoplasmic expression of β-catenin in luminal and glandular epithelial cells and increased WNT7A expression in the luminal epithelium. These results suggest that early postnatal exposure
          to a GBH enhances the sensitivity of the rat uterus to estradiol, and induces histomorphological and molecular changes associated with uterine
          hyperplasia.

        • Occupational Glyphosate and Sun Exposure Linked to Increase in Skin Cancer

          People who are exposed to glyphosate herbicides and some fungicides in their work are more likely to suffer from an aggressive form of skin cancer called cutaneous melanoma, a new Italian / Brazilian shows.
          Occupational Exposure to Pesticides With Occupational Sun Exposure Increases the Risk for Cutaneous Melanoma

          Full Study: http://www.ncbi.nlm.nih.gov

          OBJECTIVE:

          The objective of the study was to examine the association between
          occupational exposure to pesticides and cutaneous melanoma, controlling
          for all possible confounders.

          METHODS:
          A pooled analysis of two case-control studies was conducted in two different geographic areas (Italy and Brazil). Detailed pesticides exposure histories were obtained.

          RESULTS:

          Ever use of any pesticide was associated with a high risk of cutaneous melanoma (odds ratio 2.58; 95% confidence interval 1.18-5.65) in particular exposure to herbicides (glyphosate) and fungicides (mancozeb, maneb), after controlling for confounding factors. When subjects were exposed to both pesticides and occupational sun exposure, the risk increased even more (odds ratio 4.68; 95% confidence interval 1.29-17.0).

          CONCLUSIONS:
          The study suggests an augmented risk of cutaneous melanoma among subjects with exposure to pesticides, in particular among those exposed
          to occupational sun exposure.

          • Except that now we have a very large study of people who actually have occupational exposure and it showed no correlations to cancers.

          • “…, controlling for all possible [sic] confounders.”

            The study data from Italy and Brazil were pooled.

            So much for the caution typically shown by epidemiologists when interpreting their results. [/sarc]

  2. Being paid to write stories that support products and industries that cause environmental contamination and disease to the human population isn’t really worth it. I wouldn’t do it. I encourage you to dream bigger.

    • Nope glyphosate use reduces environmental contamination. It replaces riskier herbicides and when used for no till and RR crops reduces diesel use, soil compaction and thus runoff. Please try again. Keep in mind that glyphosate is less toxic than salt.

  3. Dr Milesi: Perinatal Exposure to Glyphosate-Based Herbicides Impairs Female Fertility

    A new study from Argentina has showed that perinatal exposure to low doses of a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats.

    Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats

    Authors: María M. Milesi, Virginia Lorenz, Guillermina Pacini, María R. Repetti, Luisina D. Demonte, Jorgelina Varayoud, Enrique H. Luque

    Abstract:

    Glyphosate-based herbicides (GBHs) are the most globally used herbicides raising the risk of environmental exposition. Here, we investigated whether perinatal exposure to low doses of a GBH alters thefemale reproductive performance, and/or induced second-generation effects related to congenital anomalies or growth alterations. Pregnant
    rats (F0) received a GBH through food, in a dose of 2 mg (GBH-LD: GBH-low dose group) or 200 mg (GBH-HD: GBH-high dose group) of glyphosate/kg bw/day from gestational day (GD) 9 until weaning. Body weight gain and vaginal canal-opening of F1 females were recorded. Sexually mature F1 females were mated to evaluate their reproductive performance by assessing the pregnancy rate, and on GD19, the number of corpora lutea, the implantation sites (IS) and resorption sites. To analyze second-generation effects on F2 offspring, we analyzed the fetal morphology on GD19, and assessed the fetal length and weight, and the placental weight. GBH exposure neither altered the body weight gain of F1 females, nor vaginal opening onset. Although all GBH-exposed F1 rats became pregnant, a lower number of IS was detected. F2 offspring from both GBH groups showed delayed growth, evidenced by lower fetal weight and length, associated with a higher incidence of small for gestational age fetuses. Inaddition, higher placental weight and placental index were found in F2 offspring from GBH-HD dams. Surprisingly, structural congenital anomalies (conjoined fetuses and abnormally developed limbs) were detected in the F2 offspring from GBH-HD group. In conclusion, perinatal exposure to low doses of a GBH impaired female reproductive performance and induced fetal growth retardation and structural congenital anomalies in F2 offspring.

  4. The facts are these:

    The Pesticide Industry has known from its own studies since the 1980s that glyphosate causes malformations in experimental animals at high doses

    The Pesticide Industry has known since 1993 that these effects also occur at lower and mid doses

    The German government has known since at least 1998 that glyphosate causes malformations

    The EU Commission’s expert scientific review panel knew in 1999 that glyphosate causes malformations

    The EU Commission has known since 2002 that glyphosate causes malformations. This was the year it signed off on the current approval of glyphosate.

    But this information was not made public.

  5. Dr. Nardi: Soy Milk and Glyphosate Lowers Testosterone and Damages Sperm

    A new study from Brazil has shown that soy milk and glyphoste-based herbicides, when fed to rats together, cause endocrine disruption (hormone hacking) through a decrease in testosterone levels and damage to sperm.

    Prepubertal subchronic exposure to soy milk and glyphosate leads to endocrine disruption

    Full Study: http://www.sciencedirect.com

    Authors: Jessica Nardi, Patricia Bonamigo Moras, Carina Koeppe, Eliane Dallegrave, Mirna Bainy Leal, Luciana Grazziotin Rossato-Grando

    Abstract

    Lactose intolerance is characterized by low or inexistent levels of lactase, and the main treatment consists of dietary changes, especially replacing dairy milk by soy milk. Soy contains phytoestrogens, substances with known estrogenic activity, besides, glyphosate-based herbicides are extensively used in soy crops, being frequently a residue in soy beans, bringing to a concern regarding the consumption of soy-based products, especially for children in breastfeeding period with lactose intolerance. This study evaluated the pubertal toxicity of a soy milk rich feeding (supplemented or not with glyphosate, doses of 50 and 100 mg/kg) during prepubertal period in male rats.Endocrine disruption was observed through decrease in testosterone levels, decrease in Sertoli cell number and increase in the percentage of degenerated Sertoli and Leydig cells in animals receiving soy milk supplemented with glyphosate (both doses) and in animals treated only with soy milk. Animals treated with soy milk with glyphosate (both doses) showed decrease spermatids number and increase of epididymal tail mass compared to control, and decrease in the diameter of seminiferous tubules compared to soy milk control group. Animals receiving soy milk supplemented with 100 mg/kg glyphosate showed decrease in round spermatids and increase in abnormal sperm morphology,
    compared to control.

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