Engineers are making their mark onย biotechโs hottest commodity.ย Chinese scientists [April 3] reported that they can control theย gene editing tool CRISPR-Cas9ย with light.
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Physically delivering CRISPR-Cas9 into a cell typically requires hitching the complex to a virus. … The strategy works, but using viruses as a delivery method can cause problems, such as provoking cancer or an immune response.
Researchers have proposed several alternative deliveryย materials, including gold nanoparticles, black phosphorus, metal-organic frameworks, graphene oxide, and various nanomaterials. These methods avoid some ofย the pitfalls of viruses, but still donโt give scientists control over the timing of gene editing.
Thatโs where light comes in. The authors of the new report anchored CRISPR-Cas9 to light-converting nanoparticles using a light-sensitive chemical compound.ย Then, by exposing the particles to light, the scientists triggered the release of the CRISPR-Cas9 machinery from the nanoparticles, delivering them to cells on demand.
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The system is smart not only because the timing of the releaseย ofย CRISPR-Cas9ย can be controlled, but also because it can be deliveredย fairly deepย into the body, andย controlled remotely.
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The researchers hope to apply the tool not only to cancer, but also Parkinsonโs disease and diabetes, says [Yujun Song, an author of the paper.]
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