While omega-3 fatty acid supplementation is widely used for cognitive protection, its efficacy remains controversial, and its impact on core Alzheimer’s disease (AD) pathologies in humans is not well-established.
This longitudinal study utilized data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We employed linear mixed-effects models to assess the association between omega-3 supplementation and longitudinal cognitive decline ….
Omega-3 supplementation was associated with significantly accelerated cognitive decline ….
Omega-3 supplementation may be associated with accelerated cognitive decline in older adults, potentially through adverse effects on cerebral synaptic function rather than classical AD proteinopathies. These findings challenge the prevailing view of omega-3 as uniformly beneficial and highlight the need for a cautious reassessment of its widespread use for cognitive protection.
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While prior research has predominantly emphasized their anti-inflammatory and neurotrophic mechanisms, our results suggest a previously underrecognized possibility that omega-3 supplementation may, in some contexts, adversely affect synaptic integrity, ultimately counteracting its short-term benefits.
