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‘De novo genes’: How natural selection creates new genes from nothing

| | October 30, 2019

In the depths of winter, water temperatures in the ice-covered Arctic Ocean can sink below zero. That’s cold enough to freeze many fish, but the conditions don’t trouble the cod. A protein in its blood and tissues binds to tiny ice crystals and stops them from growing.

But then [evolutionary biologist Helle Tessand Baalsrud] stumbled on studies suggesting that genes do not always evolve from existing ones, as biologists long supposed. Instead, some are fashioned from desolate stretches of the genome that do not code for any functional molecules. When she looked back at the fish genomes, she saw hints this might be the case: the antifreeze protein — essential to the cod’s survival — had seemingly been built from scratch.

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The cod is in good company. In the past five years, researchers have found numerous signs of these newly minted ‘de novo’ genes in every lineage they have surveyed. These include model organisms such as fruit flies and mice, important crop plants and humans; some of the genes are expressed in brain and testicular tissue, others in various cancers.

The ability of organisms to acquire new genes in this way is testament to evolution’s “plasticity to make something seemingly impossible, possible”, says [geneticist] Yong Zhang,

Read full, original post: How evolution builds genes from scratch

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