Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats.
In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts. These results were published [June 2] in Cell Reports.
โSeeing that little human organ there inside the animal โ brown, looking like a liver โ that was pretty cool. This thing that looks like a liver and functions like a liver came from somebodyโs skin cells,โ said senior author Alejandro Soto-Gutierrez.
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These mini livers secrete bile acids and urea, just like a normal liver, except theyโre made-to-order in the lab using patient cells.
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In all cases, blood flow problems had developed within and around the graft, but the transplanted mini livers worked โ the rats had human liver proteins in their blood serum.
Soto-Gutierrez is optimistic that this research is not merely a stepping-stone on the path toward growing replacement organs in a lab, but also a useful tool in its own right.
โThe long-term goal is to create organs that can replace organ donation, but in the near future, I see this as a bridge to transplant,โ Soto-Gutierrez said. โFor instance, in acute liver failure, you might just need hepatic boost for a while instead of a whole new liver.โ
