Glyphosate weedkiller unlikely to impact ovarian function, studies find

Monsanto Roundup pesticide ap img

Exposure to the chemical glyphosate changed the level of some ovarian proteins in mice but did not impact ovarian steroid production, an indication glyphosate may not adversely affect reproduction, according to a new study.

Two studies, published in the peer-reviewed academic journals Toxicology and Applied Pharmacology and Reproductive Toxicology, analyzed how ovarian function in mice responded to various levels of exposure to glyphosate, a chemical extensively used to kill weeds. The research found the highest exposure levels included in the experiments resulted in increased ovarian weight and follicle number, but Aileen Keating, an associate professor of animal science at Iowa State University and lead author, said the research did not uncover evidence that glyphosate affects the healthy functioning of ovaries.

“The big takeaway is that while we did find some changes in ovarian proteins, many of the endpoints we examined were not altered by glyphosate exposure,” Keating said.

Keating, whose research focuses on reproductive health, said it’s unclear if the increased ovarian size or altered protein abundance that resulted from the highest exposure level could cause changes in the ability of mice to reproduce. Answering that question will require further study, she said. The study found glyphosate exposure did not affect heart, liver, spleen, kidney or uterus weights. Keating said the study’s conclusions largely agreed with findings published years ago meant to determine how the chemical can be used safely.

Related article:  Genetic Literacy Project’s Top 6 Stories for the Week – Oct. 23, 2017

The researchers introduced glyphosate to groups of mice orally, mimicking how humans could be exposed to glyphosate residue in water or in crops used for food production. Groups of mice were exposed to different glyphosate levels and for periods of 5, 10 or 20 weeks.  The researchers chose the doses, measured in milligrams per kilogram of bodyweight, to approximate potential glyphosate levels that humans could be exposed to.

Follow the latest news and policy debates on agricultural biotech and biomedicine? Subscribe to our newsletter.

However, Keating noted that it remains unclear how much glyphosate humans are exposed to regularly, which made it difficult to judge what levels were appropriate for the experiments. Additionally, they used only the active compound contained in weed treatments, not the additional ingredients.

The use of glyphosate has sparked controversy regarding its proposed health effects. Accordingly, Keating said the researchers designed the study to be as unbiased as possible. For instance, the scientists didn’t know the glyphosate treatment of individual samples as they conducted their analysis, which meant perceived expectations or biases could not affect the results.

“It’s a commonly used chemical, and there’s been some alarm in the media about its use,” she said. “We need more well designed, independent studies to see if this is something we should be concerned about.”

Read the original post

Outbreak
Outbreak Daily Digest
Biotech Facts & Fallacies
Talking Biotech
Genetics Unzipped
Infographic: What are mRNA COVID-19 vaccines and how do they work?

Infographic: What are mRNA COVID-19 vaccines and how do they work?

As of 1 December 2020, thirteen vaccines have reached the final stage of testing: where they are being given to ...
favicon

Environmental Working Group: EWG challenges safety of GMOs, food pesticide residues

Known by some as the "Environmental Worrying Group," EWG lobbies ...
m hansen

Michael Hansen: Architect of Consumers Union ongoing anti-GMO campaign

Michael K. Hansen (born 1956) is thought by critics to be ...
News on human & agricultural genetics and biotechnology delivered to your inbox.
glp menu logo outlined

Newsletter Subscription

Optional. Mail on special occasions.
Send this to a friend