CRISPR is 10: A decade of gene editing refinements presents new ways to address agricultural diseases thought to be incurable

Jennifer Doudna holding a model beginning to edit a stretch of blue DNA. The orange RNA binds to the defined DNA target; the white Cas9 enzyme cuts the DNA. Credit: Jana Ašenbrennerová
Jennifer Doudna holding a model beginning to edit a stretch of blue DNA. The orange RNA binds to the defined DNA target; the white Cas9 enzyme cuts the DNA. Credit: Jana Ašenbrennerová

Because CRISPR applications promise so many benefits, we are impatient to see them realized. Indeed, we may complain that the development of CRISPR therapies is too slow. Nonetheless, a handful of CRISPR therapies have advanced to the early stages of clinical trials, including therapies for sickle-cell anemia, HIV disease, and acute myeloid leukemia.

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We are eager to see CRISPR succeed not just in medicine, but in other application areas where humanity faces serious challenges—areas that include crop production, bioenergy, manufacturing, and environmental remediation. To hasten progress in all these areas, scientists are working diligently to add tools to the CRISPR toolbox.

[CRISPR co-creator Jennifer] Doudna thinks that the agriculture and climate applications have the potential to have an even more significant impact worldwide.

“We’re starting to see CRISPR-edited agricultural products now,” Doudna noted. “We’ll see many more over the coming years addressing issues like food security, drought and flood tolerance, reducing pesticide and fertilizer use, eliminating agricultural emissions, as well as carbon removal and sequestration.”

For all of the uncertainty that lies ahead, one thing we can all be sure about is that CRISPR will likely have a role in shaping the future of individuals and the planet.

This is an excerpt. Read the original post here

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