A single dose of psilocybin appears more effective than drugs in treating depression

magic-mushrooms-brain

A new study compares psilocybin — the active compound in magic mushrooms, with a common antidepressant medication.

  • During 6 months of follow-up, both drugs effectively improved depressive symptoms.
  • Psilocybin, however, seemed to provide additional benefits, including improved psychological connectedness and social functioning.
  • This is a small study, and scientists still need to conduct more research to understand the longterm effects of psilocybin.
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[T]hese studies identified few serious side effects, and rather than a daily dose, the treatment appears to be effective for weeks or months after just a single dose.

“The excitement is justified, given psilocybin’s potential to treat resistant depression, anxiety, and post-traumatic stress disorder (PTSD),” said [Ozan Toy, MD, a neuropsychiatrist not involved in this study]. “Many studies have demonstrated significant benefits for PTSD.”

Still, Toy added a word of caution: “Concerns remain about long-term effects, accessibility, and better safety data to understand the risks and benefits.”

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