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International study hopes to identify genetic markers to predict response to antidepressants

A group of research centers spanning five continents is in the middle of a clinical trial intended to identify genetic and other markers that can predict response to three antidepressants. According to Subhdeep Virk, a psychiatrist and principal investigator of the study at Ohio State’s Wexner Medical Center, the International Study to Predict Optimized Treatment of Depression, or iSPOT-D, is the largest biomarker discovery effort to identify predictors for depression treatment response. Because depression is a genetically heterogeneous disorder, smaller studies looking at single markers have not shown much success, Virk told PGx Reporter this week. 

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