A genetic mutation may be responsible for essential tremor that runs in families, researchers found. Exome sequencing studies of several family members that have been diagnosed with the condition revealed a mutation in the fused in sarcoma (FUS) gene that was common among all those who had definite or probable disease, Guy Rouleau, PhD, of the University of Montreal, and colleagues reported in the American Journal of Human Genetics.
Essential tremor is one of the most common adult-onset movement disorders, largely affecting the upper limbs. Despite a strong genetic basis — it appears to run in families — no definitive genetic mutations have been reported.
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