Mouse eggs can now be cooked up from scratch. Using stem cells, a Japanese team has created healthy eggs that, once fertilised, grow into normal mouse pups.
Both egg and sperm cells start life as primordial germ cells (PGCs). Last year, Katsuhiko Hayashi and his colleagues at Kyoto University in Japan found they could generate PGC-like cells from either mouse embryonic stem cells or body cells that can turn into stem cells – known as induced pluripotent stem cells or IPSCs. What’s more, the team managed to coax these PGC-like cells into becoming sperm (Cell, DOI: 10.1016/j.cell.2011.06.052).
View the original article here: Mouse eggs created from stem cells