Unreliability of genome assembly contest results prompts soul-searching

In July 2011, as part of a “Assemblathon” contest, 21 teams submitted 43 attempts to build assemblers to assemble three genomes from scratch: that of a bird (budgerigar), a fish (the Lake Malawi cichlid) and a snake (the boa constrictor).

But different assemblers – and the same assemblers in the hands of different teams – did not give consistent results. And that’s the same thing that happened in previous contest.

Bioinformatician C. Titus Brown of Michigan State University wrote on his blog that “as a field, we have pretended that genome assembly is a reliable exercise and that the results can be trusted; the Assemblathon 2 paper shows that that’s wrong.”

Read the full article here: Genome assembly contest prompts soul-searching

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