Scientists find skin-to-liver cell transformation shortcut

Scientists have differentiated human induced pluripotent stem cells (iPSCs) into hepatocytes in a dish, but faced challenges using these cells therapeutically. Most iPSC-derived liver cells do not adequately proliferate after transplantation or function exactly like adult hepatocytes do. Now, researchers from the University of California, San Francisco (UCSF), have differentiated human hepatocytes with a modified technique that bypasses pluripotency, and used these cells to repopulate a mouse liver. Their work was published in Nature February 23.

“I really like this paper. It’s a step forward in the field,” said Alejandro Soto-Gutiérrez, an assistant professor of pathology from the University of Pittsburgh, who was not involved in the work. “The concept is reprogramming, but with a shortcut, which is really cool.”

Read the full, original story: Skin-to-Liver Cell Shortcut

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